中国肿瘤生物治疗杂志2023，Vol.30Issue(12)：1099-1104,6.DOI:10.3872/j.issn.1007-385x.2023.12.009
益气活血汤改善恶性肿瘤患者的癌痛及癌因性疲乏
Clinical study of Yiqi Huoxue decoction on improving cancer pain and cancer-related fatigue in patients with malignant tumors
摘要
Abstract
Objective:To analyze the improvement effects of Yiqi Huoxue decoction on cancer pain and cancer-related fatigue(CRF)in patients with malignant tumors.Methods:82 patients with malignant tumors(qi and blood deficiency syndrome)who were admitted into the Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine and diagnosed with cancer-related fatigue(CRF)between January 2020 and December 2022 were selected and divided into the control group and the observation group by the remainder grouping method of the random number table,with 41 cases in each group.Patients in the control group received conventional symptomatic treatments such as pain relief,vomit stopping and phlegm reduction as well as health and psychological guidance while patients in the observation group was given the Yiqi Huoxue decoction treatment in addition to the intervention administered to the control group.Before and after 4 weeks of treatment(1 course of treatment),the clinical TCM efficacy of the two groups was evaluated by the changes of TCM syndromes scores.The clinical efficacy of CRF was assessed by Revised Piper Fatigue Scale(RPFS).The differences in cancer pain were compared by Numerical Rating Scale(NRS).Peripheral blood fibrinogen(FIB)and D-dimer(D-D)were detected to assess the differences in coagulation function,and the safety of Yiqi Huoxue decoction treatment was assessed by patients'liver and kidney function indexes.Results:Before treatment,the differences between the TCM syndromes scores,RPFS scores,NRS score,peripheral blood FIB and D-D of the two groups were not statistically significant(all P>0.05).After 4 weeks of treatment,the scores of syndromes such as fatigue and tiredness,pale or sallow complexion,spontaneous sweating,insomnia and forgetfulness and hand and foot numbness well as total scores of both groups decreased compared with those before treatment(all P<0.05),and all the scores of the observation group were lower than those of the control group(all P<0.05),and the clinical TCM efficacy of the observation group was significantly higher than that of the control group(P<0.05).After 4 weeks of treatment the dimension scores and total scores of RPFS of the two groups were reduced compared to those before treatment(all P<0.05).The dimension scores of behaviors,emotion and feeling and total score of RPFS of the observation group were lower than those of the control group(all P<0.05)while the clinical efficacy of CRF was significantly higher than that of the control group(P<0.05).After 4 weeks of treatment,NRS score and peripheral blood FIB and D-D of both groups were reduced compared with those before treatment(all P<0.05),and the scores of the observation group were lower than those of the control group(all P<0.05).No obvious abnormal indicators of liver function and kidney function occurred in the two groups during treatment,suggesting that Yiqi Huoxue decoction was safe.Conclusion:Yiqi Huoxue decoction can correct the syndrome of qi and blood deficiency,improve the body's coagulation function,and promote the relief of CRF and cancer pain in patients with malignant tumors.Therefore,it has high clinical application value.关键词
恶性肿瘤/癌因性疲乏/癌痛/益气活血汤/凝血功能Key words
malignant tumors/cancer-related fatigue(CRF)/cancer pain/Yiqi Huoxue decoction/coagulation function分类
医药卫生引用本文复制引用
徐珩,曾永蕾,郝皖荣,丁艳琪,夏克春,周先阳,马丽,吴勇,冷玉玲..益气活血汤改善恶性肿瘤患者的癌痛及癌因性疲乏[J].中国肿瘤生物治疗杂志,2023,30(12):1099-1104,6.基金项目
安徽省中医药传承创新项目(No.2020ccyb05) （No.2020ccyb05）
曾永蕾安徽省名医工作室项目[No.(2020)10号] （2020）
