原发灶不明肿瘤的诊断技术现状及进展
Current Status and Progress of Diagnostic Techniques for Cancer of Unknown Primary
摘要
Abstract
Cancer of unknown primary(CUP)is a heterogeneous tumor type that has been diagnosed as a metastatic tumor by pathological examination,but the primary tumor cannot be identified through comprehensive clinical examination.The incidence of CUP accounts for approximately 1％-2％ of all tumors.CUP progresses rapidly and has a short course.The treatment and prognosis of patients with CUP are closely linked to the primary site.In clinical settings,identifying the primary tumor remains challenging.Scholars have focused on improving the detection rate.Novel technologies,such as gene expression profiling,high-throughput sequencing,epigenetics,and liquid biopsy,have been successively applied to identify the primary tumor of CUP accurately,sensitively and specifically.With the guidance of molecular diagnosis,targeted therapy,immunotherapy,and combination therapy will usher in the era of precision treatment for CUP,which may become a typical example for individualized therapy.关键词
原发灶不明肿瘤/分子诊断/基因检测/靶向治疗/免疫治疗Key words
Cancer of unknown primary/Molecular Diagnostics/Gene Detection/Targeted Therapy/Immunotherapy分类
医药卫生引用本文复制引用
戚鹏,孙益丰,徐清华,周晓燕..原发灶不明肿瘤的诊断技术现状及进展[J].肿瘤防治研究,2023,50(12):1160-1164,5.基金项目
National Natural Science Foundation of China(No.81470353,81870155) （No.81470353,81870155）
Innovation Group Project of Shanghai Municipal Health Commission(No.2019CXJQ03) （No.2019CXJQ03）
Shanghai Science and Technology Development Foundation(No.19MC1911000) （No.19MC1911000）
Shanghai Municipal Key Clinical Specialty(No.shslczdzk01301) （No.shslczdzk01301）
Innovation Program of Shanghai Science and Technology Committee(No.20Z11900300) （No.20Z11900300）
Clinical Research Plan of SHDC(No.SHDC2020CR3046B)国家自然科学基金面上项目(81470353,81870155) （No.SHDC2020CR3046B）
上海市卫生计生委协同创新集群项目(2019CXJQ03) （2019CXJQ03）
上海市科学技术委员会科研计划项目(19MC1911000) （19MC1911000）
上海市临床重点专科建设项目—病理科(shslczdzk01301) （shslczdzk01301）
上海市科学技术委员会"科技创新行动计划"医学创新研究专项(20Z11900300) （20Z11900300）
申康医院发展中心临床创新三年行动计划-重大临床研究项目(SHDC2020CR3046B) （SHDC2020CR3046B）
