浙江医学2023，Vol.45Issue(23)：2518-2521,2530,5.DOI:10.12056/j.issn.1006-2785.2023.45.23.2023-135
双背侧前额叶低频重复经颅磁刺激对缓解期精神分裂症患者认知功能的影响
The effect of low-frequency repetitive transcranial magnetic stimulation on cognitive function in patients with schizophrenia in remission
摘要
Abstract
Objective To explore the effect of low-frequency repetitive transcranial magnetic stimulation of the bilateral dorsal prefrontal lobe on cognitive function in patients with schizophrenia in remission.Methods Forty patients with remission stage schizophrenia admitted to the Affiliated Mental Health Center of Zhejiang University School of Medicine from January 2020 to December 2022 were selected as the study subjects.They were randomly divided into an observation group(olanzapine combined with transcranial magnetic stimulation)and a control group(olanzapine combined with pseudo stimulation therapy)using a random number table method,with 20 patients in each group.Observe and compare the positive and negative syndrome scale(PANSS)scores,repeatable battery for the assessment of neuropsychological status(RBANS)scores,serum brain-derived neurotrophic factor(BDNF)levels,and incidence of adverse reactions between two groups of patients before treatment and 10 days after treatment.Results There was no statistically significant difference in PANSS factor scores,RBANS factor scores,and serum BDNF levels between the two groups of patients before treatment(all P＞0.05);after 10 days of treatment,the scores of positive symptoms,negative symptoms,and general pathological symptoms in both groups of patients were significantly reduced.The scores of immediate memory,visual breadth,speech function,attention,delayed memory,and serum BDNF levels were significantly increased.The observation group showed more significant changes compared to the control group,and the differences were statistically significant(all P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups of patients(P＞0.05).Conclusion The low-frequency repetitive transcranial magnetic stimulation of the bilateral dorsal prefrontal lobe has a significant effect on relieving schizophrenia,improving the patient's mental symptoms,cognitive function,and neurological function without increasing the incidence of adverse reactions.关键词
双背侧前额叶/低频/重复经颅磁刺激/精神分裂症/认知功能Key words
Bilateral dorsal prefrontal lobe/Low-frequency/Repetitive transcranial magnetic stimulation/Schizo-phrenia/Cognitive function引用本文复制引用
申变红,张开元,汪程鹏,高可润,张智雯,汤剑平..双背侧前额叶低频重复经颅磁刺激对缓解期精神分裂症患者认知功能的影响[J].浙江医学,2023,45(23):2518-2521,2530,5.基金项目
浙江省医药卫生科技计划项目(2019RC073) （2019RC073）
