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Platelet factor 4 induces bone loss by inhibiting the integrin α5-FAK-ERK pathway

Wei Li Qiwei Zhang Ranli Gu Lijun Zeng Hao Liu

动物模型与实验医学(英文)2023,Vol.6Issue(6):573-584,12.
动物模型与实验医学(英文)2023,Vol.6Issue(6):573-584,12.DOI:10.1002/ame2.12342

Platelet factor 4 induces bone loss by inhibiting the integrin α5-FAK-ERK pathway

Platelet factor 4 induces bone loss by inhibiting the integrin α5-FAK-ERK pathway

Wei Li 1Qiwei Zhang 2Ranli Gu 3Lijun Zeng 3Hao Liu4

作者信息

  • 1. Department of Oral Pathology,Peking University School and Hospital of Stomatology,National Center for Stomatology,National Clinical Research Center for Oral Diseases,National Engineering Research Center of Oral Biomaterials and Digital Medical Devices,Beijing Key Laboratory of Digital Stomatology,National Health Commission Key Laboratory of Digital Technology of Stomatology,Peking University,Beijing,China||Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions,Chinese Academy of Medical Sciences,Beijing,China
  • 2. Department of Orthopedics,Beijing Hospital and National Center of Gerontology and Institute of Geriatrics Medicine,Chinese Academy of Medical Sciences,Beijing,China||Department of Orthopedics,Beijing Eden Hospital,Beijing,China
  • 3. Department of Prosthodontics,Peking University School and Hospital of Stomatology,National Center for Stomatology,National Clinical Research Center for Oral Diseases,National Engineering Research Center of Oral Biomaterials and Digital Medical Devices,Beijing Key Laboratory of Digital Stomatology,National Health Commission Key Laboratory of Digital Technology of Stomatology,Peking University,Beijing,China
  • 4. The Central Laboratory,Peking University School and Hospital of Stomatology,National Center for Stomatology,National Clinical Research Center for Oral Diseases,National Engineering Research Center of Oral Biomaterials and Digital Medical Devices,Beijing Key Laboratory of Digital Stomatology,National Health Commission Key Laboratory of Digital Technology of Stomatology,Peking University,Beijing,China
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摘要

关键词

bone loss/bone marrow mesenchymal stem cells/integrin α 5/osteogenesis/platelet factor 4

Key words

bone loss/bone marrow mesenchymal stem cells/integrin α 5/osteogenesis/platelet factor 4

引用本文复制引用

Wei Li,Qiwei Zhang,Ranli Gu,Lijun Zeng,Hao Liu..Platelet factor 4 induces bone loss by inhibiting the integrin α5-FAK-ERK pathway[J].动物模型与实验医学(英文),2023,6(6):573-584,12.

基金项目

This work was supported by grants from the National Natural Science Foundation of China(81700935),the Beijing Natural Science Foundation(L222145),Clinical Medicine Plus X—Young Scholars Project,Peking University,the Fundamental Research Funds for the Central Universities(PKU2023LCXQ017),and CAMS Innovation Fund for Medical Sciences(2019-I2M-5-038). (81700935)

动物模型与实验医学(英文)

OACSCD

2096-5451

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