纺织高校基础科学学报2023，Vol.36Issue(6)：22-29,8.DOI:10.13338/j.issn.1006-8341.2023.06.004
丝素蛋白/海藻酸钠水凝胶的制备及其释药性能
Preparation and drug release properties of silk fibroin/sodium alginate hydrogel
摘要
Abstract
In order to improve the loading rate and sustained release rate of hydrogels,silk fibroin/sodium alginate hydrogels were prepared by crosslinking reaction between silk fibroin with sodium alginate,using N-hydroxysuccinimide and ethyl(3-dimethylaminopropyl)carbodiimide salt as catalysts and citric acid as crosslinking agent.The structure,morphology,dissolution rate,water absorption,drug loading rate and drug release rate of the hydrogels were tested.The results show that the optimal preparation conditions of silk fibroin/sodium alginate hydrogel are:the mass fraction of silk fibroin 2.5％,the mass fraction of citric acid 2.5％,the mass fraction of sodium alginate 4.5％,and the mass fraction of catalyst(mass ratio 1∶1)0.5％.The infrared spectrum of the hydrogel prepared under this condition contains the characteristic absorption peaks of silk fibroin and sodium alginate.Its morphology is porous.After 24 h,the dissolution rate is 11.4％,the water absorption rate is about 70％,and the maximum drug loading rate is about 50％.In the buffer solution with pH=7.4,the drug release rate is close to 75％after 8 h.It shows good drug release performance.关键词
丝素蛋白/水凝胶/柠檬酸/海藻酸钠/释药性能Key words
silk fibroin/hydrogel/citric acid/sodium alginate/drug release property分类
轻工业引用本文复制引用
巢梦颖,凌新龙,刘雨鹭,黄幸菊,林海涛..丝素蛋白/海藻酸钠水凝胶的制备及其释药性能[J].纺织高校基础科学学报,2023,36(6):22-29,8.基金项目
广西科技大学博士基金(17z07) （17z07）
广西大学生创新创业训练计划资助项目(S202110594013) （S202110594013）
