高等学校化学学报2024，Vol.45Issue(1)：1-9,9.DOI:10.7503/cjcu20230312
聚赖氨酸抗菌肽改性明胶多功能水凝胶的构建与应用
Construction and Application of Polylysine Peptide Modified Gelatin Multifunctional Hydrogel
摘要
Abstract
The ε-polylysine(EPL)antibacterial peptide was grafted onto gelatin to synthesize EPL-modified gelatin(GEL-E),afterwards,a multifunctional hydrogel,GEL-E/CMC/OCS hydrogel,with injectable,self-healing and antibacterial properties was prepared using GEL-E,carboxymethyl chitosan(CMC)and chondroitin oxysulfate(OCS).The experimental results showed that the hydrogel prepared has high energy storage modulus,elastic deformation,self-healing,injectable and antibacterial properties.Dipotassium glycyrrhizinate(DG)was loaded into hydrogel,which endowed the hydrogel with anti-inflammatory properties and wound healing ability.The results showed that the drug release rate could reach 100%.Meanwhile,the cell compatibility and the ability of promoting cell migration were evaluated,the results showed that the hydrogels presented very low cytotoxicity and could promote cell migration.All the above results indicated that the GEL-E/CMC/OCS hydrogel has good mechanical properties,biocompatibility and ability to promote cell migration,and has broad application prospects in the field of promoting wound healing.关键词
多功能水凝胶/聚赖氨酸/抗菌肽/伤口敷料Key words
Multifunctional hydrogel/Polylysine/Antimicrobial peptide/Wound dressing分类
化学化工引用本文复制引用
江云静,黄童黛,曹玉玉,白荣先,吴杰,王祖曦,孙红梅..聚赖氨酸抗菌肽改性明胶多功能水凝胶的构建与应用[J].高等学校化学学报,2024,45(1):1-9,9.基金项目
湖北工业大学国家细胞调控与分子药物"111"引智基地青年项目(批准号:XBTK-2022007)资助.Supported by the HBUT National"111"Center for Cellular Regulation and Molecular Pharmaceutics,China(No.XBTK-2022007). （批准号:XBTK-2022007）
