口腔疾病防治Issue(3)：209-215,7.DOI:10.12016/j.issn.2096-1456.2024.03.007
牙周炎与干燥综合征的因果关系:一项孟德尔随机化研究
Bidirectional casual effects between periodontitis and Sjögren's syndrome:a Mendelian randomization study
摘要
Abstract
Objective To evaluate the bidirectional association between periodontitis and Sjögren's syndrome us-ing the Mendelian randomization(MR)method.Methods Genome-wide association study(GWAS)data of periodonti-tis(N=45 563)and Sjögren's syndrome(N=214 435)were selected to meet the requirements of the same ethnicity and different regions.Inverse variance-weighted(IVW),MR-Egger,and weighted median(WM)tests were used to evalu-ate the causal effect.Cochran's Q statistics,MR-Egger intercept,MR-PRESSO and leave-one-out analysis were used as sensitivity analyses to assess the stability and reliability of the results.Results After screening,the GWAS data of Sjögren's syndrome were based on the Finnish region,and the periodontitis GWAS data were based on the UK region,both of which originated from European ancestry.Using IVW(OR=1.017,95％CI=0.956-1.082),MR-Egger(OR=0.985,95％CI=0.956-1.082),and WM(OR=1.021,95％CI=0.948-1.099),no causal effect of Sjögren's syndrome on periodontitis was found using any of the three methods.Conversely,no causal effect of periodontitis on Sjögren s syn-drome was found(IVW,OR=1.024,95％CI=0.852-1.230;MR-Egger,OR=0.978,95％CI=0.789-1.212;WM,OR=1.024,95％CI=0.846-1.260).The sensitivity analyses indicated that the results were stable and reliable.Cochran's Q test and MR-PRESSO revealed that there was no significant heterogeneity among the instrumental variables,which included single nucleotide polymorphisms(SNPs).The intercept of MR-Egger regression indicated no pleiotropy in the included SNPs.No individual SNP was found that significantly affected the results using the leave-one-out method.Conclusion This study does not support a bidirectional causal effect between periodontitis and Sjögren's syndrome.关键词
牙周炎/干燥综合征/孟德尔随机化/全基因组关联分析/因果关联/双向因果/混杂因素/逆方差加权Key words
periodontitis/Sjögren's syndrome/Mendelian randomization/genome-wide association study/causal association/bidirectional casual association/confounder/inverse variance-weighted分类
医药卫生引用本文复制引用
谢培莉,郭辰淼,余挺..牙周炎与干燥综合征的因果关系:一项孟德尔随机化研究[J].口腔疾病防治,2024,(3):209-215,7.基金项目
This study was supported by the grants from Guangdong Basic and Applied Basic Research Foundation(No.2023A1515030037,No.2022A1515010497).广东省基础与应用基础研究基金(2023A1515030037 （No.2023A1515030037,No.2022A1515010497）
2022A1515010497) （）
