口腔疾病防治Issue(3)：223-228,6.DOI:10.12016/j.issn.2096-1456.2024.03.009
去分化脂肪细胞及其在口腔颌面部骨组织工程中应用的研究进展
Research progress on dedifferentiated fat cells and their application in oral and maxillofacial bone tissue engi-neering
摘要
Abstract
The identification of suitable seed cells represents a critical scientific problem to be solved in the field of oral and maxillofacial bone tissue regeneration.The application of adipose-derived stem cells(ASCs)in tissue and organ repair and regeneration has been studied extensively.In recent years,dedifferentiated fat(DFAT)cells have also shown broad application prospects in the field of bone tissue engineering.DFAT cells express stem cell-related markers and have the potential to differentiate into adipocytes,osteoblasts,chondrocytes,nerve cells,cardiomyocytes and endothelial cells.In addition,DFAT cells also have the advantages of minimally invasive acquisition,strong proliferation and high homogeneity.Currently,all studies involving the application of DFAT cells in scaffold-based and scaffold-free bone tis-sue engineering can confirm their effectiveness in promoting bone regeneration.However,cytological research still faces some challenges,including relatively low cell culture purity,unclear phenotypic characteristics and undefined dediffer-entiation mechanisms.It is believed that with the continuous development and improvement of isolation,culture,identi-fication and directional induction of osteogenic differentiation methods,DFAT cells are expected to become excellent seed cells in the field of oral and maxillofacial bone tissue engineering in the future.关键词
再生医学/组织工程学/去分化脂肪细胞/细胞去分化/骨再生/颌面修复术/脂肪干细胞/脂肪细胞Key words
regenerative medicine/tissue engineering/dedifferentiated fat cells/cell dedifferentiation/bone regeneration/maxillofacial prosthesis/adipose-derived stem cells/adipocytes分类
医药卫生引用本文复制引用
沈荧怡,曹希萌,胥春..去分化脂肪细胞及其在口腔颌面部骨组织工程中应用的研究进展[J].口腔疾病防治,2024,(3):223-228,6.基金项目
This study was supported by the grants from National Natural Science Foundation of China(No.82071157) （No.82071157）
Original Ex-ploration Project of Shanghai Ninth People's Hospital,Shanghai JiaoTong University School of Medicine(No.JYYC002).国家自然科学基金项目(82071157) （No.JYYC002）
上海交通大学医学院附属第九人民医院原创探索项目(JYYC002) （JYYC002）
