临床与病理杂志2023，Vol.43Issue(10)：1769-1777,9.DOI:10.11817/j.issn.2095-6959.2023.230078
非转移性乳腺癌循环肿瘤细胞与临床病理特征的关系
Correlation between circulating tumor cells and clinicopathological features in non-metastatic breast cancer
摘要
Abstract
Objective:To investigate the correlation between the quantity of circulating tumor cell(CTC)and the pathological characteristics of non-metastatic breast cancer patients after chemotherapy. Methods:This study focused on one hundred and ninety non-metastatic breast cancer patients who underwent chemotherapy at the First People's Hospital of Xinxiang from October 2019 to January 2022.After chemotherapy,CTC detection was performed using the CytoSorter system,and the correlation between the post-chemotherapy CTC quantity and the clinicopathological characteristics of non-metastatic breast cancer was analyzed. Results:The detection rate of post-chemotherapy CTC in non-metastatic breast cancer patients was 43.7%(83/190).Post-chemotherapy CTC were significantly correlated with tumor maximum diameter,clinical stage,T stage,N stage,lymph node metastasis,human epidermal growth factor receptor 2(HER-2)expression,progesterone receptor(PR)expression,Ki-67 expression,and androgen receptor(AR)expression in non-metastatic breast cancer patients(all P<0.05).The results of binary logistic regression analysis showed that clinical stage(P=0.010),T stage(P=0.001),N stage(P=0.046),lymph node metastasis(P<0.001),and PR expression(P=0.008)significantly influenced the quantity of post-chemotherapy CTC in non-metastatic breast cancer. Conclusion:The quantity of CTC after chemotherapy in non-metastatic breast cancer patients may be correlated with tumor maximum diameter,clinical stage,T stage,N stage,lymph node metastasis,HER-2,PR,Ki-67,and AR expression.CTC testing may assist in the post-chemotherapy stratified management of non-metastatic breast cancer patients.关键词
非转移性乳腺癌/循环肿瘤细胞/化学治疗/病理特征Key words
non-metastatic breast cancer/circulating tumor cells/chemotherapy/pathological features引用本文复制引用
郭艳风,郭元丽,王全志,周红艳..非转移性乳腺癌循环肿瘤细胞与临床病理特征的关系[J].临床与病理杂志,2023,43(10):1769-1777,9.基金项目
河南省重点研发与推广专项(科技攻关)(222102310421).This work was supported by the Henan Provincial Key Research&Development and Promotion Special Program(Science and Technology Tackling),China(222102310421). （科技攻关）
