临床与病理杂志2023，Vol.43Issue(10)：1778-1785,8.DOI:10.11817/j.issn.2095-6959.2023.220103
DCE-MRI定量参数Ktrans、Kep、Ve值与乳腺癌分子分型及预后的关系
Relationship between DCE-MRI quantitative parameters Ktrans,Kep,Ve values and molecular subtypes and prognosis in breast cancer
摘要
Abstract
Objective:To investigate the relationship between dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)quantitative parameters[volume transfer constant(Ktrans),rate constant(Kep),extravascular extracellular interstitial volume ratio(Ve)]and molecular subtypes as well as prognosis in breast cancer patients. Methods:Clinical data from 119 breast cancer patients,who admitted to Cangzhou People's Hospital from April 2020 to November 2022,were selected.All patients underwent DCE-MRI examination,and the measured values of Ktrans,Ve,Kep were sorted out and compared among breast cancer patients with different molecular subtypes and different expressions of progesterone receptor(PR),estrogen receptor(ER)and human epidermal growth factor receptor 2(HER-2).Spearman analysis was used to investigate the correlation between different quantitative parameters of DCE-MRI and positive expressions of ER,PR,and HER-2. Results:Patients with positive expressions of ER and PR had lower Ktrans and Kep values than those with negative expressions(all P<0.05).There was no significant difference in Ve values between ER and PR positive and negative expression(all P>0.05).Patients with HER-2 positive expression had higher Ve values than those with negative expression(P<0.05),but there was no significant difference in Ktrans and Kep values between HER-2 positive and negative expression(both P>0.05).Ktrans and Kep were negatively correlated with positive expressions of ER and PR(r=-0.562,-0.592,-0.601,-0.592,respectively,all P<0.05),but showed no significant correlation with HER-2 positive expression(r=-0.163,-0.182,respectively,both P>0.05).Ve was positively correlated with HER-2 positive expression(r=0.582,P<0.05),but had no significant correlation with positive expressions of ER and PR(r=0.156,0.106,respectively,both P>0.05).The comparison of Ktrans among different molecular subtypes of breast cancer was as follows:Luminal A<Luminal B<HER-2 overexpression<triple negative breast cancer(TNBC);the comparison of Kep values was as follows:Luminal A<HER-2 overexpression<Luminal B<TNBC;the comparison of Ve values was as follows:TNBC<Luminal A<Luminal B<HER-2 over-expression(all P<0.05).The diagnostic accuracy of DCE-MRI for molecular subtypes of breast cancer was 96.64%(115/119),which was consistent with the results of pathological diagnosis(Kappa=0.966,P<0.05). Conclusion:The quantitative parameters of DCE-MRI(Ktrans,Kep,Ve)can be used as effective parameters for molecular subtyping and prognosis of breast cancer,and they are significantly correlated with ER,PR,and HER-2 expressions.关键词
乳腺癌/分子分型/动态增强磁共振成像/相关性/定量参数Key words
breast cancer/molecular subtypes/dynamic contrast-enhanced magnetic resonance imaging/correlation/quantitative parameters引用本文复制引用
张倩,戴世鹏,邵迎华..DCE-MRI定量参数Ktrans、Kep、Ve值与乳腺癌分子分型及预后的关系[J].临床与病理杂志,2023,43(10):1778-1785,8.基金项目
沧州市重点研发计划指导项目(213106021).This work was supported by the Key Research and Development Plan Guidance Project of Cangzhou City,China(213106021). （213106021）
