临床与病理杂志2023，Vol.43Issue(10)：1786-1792,7.DOI:10.11817/j.issn.2095-6959.2023.230057
肉芽肿小叶性乳腺炎导管病理学特征
Pathological characteristics of granulomatous lobular mastitis ductopathy
摘要
Abstract
Objective:Patients with granulomatous lobular mastitis often exhibit concurrent ductal dilation in the breast with the presence of abundant lipid-like secretions with ducts.This study aims to investigate the pathological characteristics of breast ducts in patients with granulomatous lobular mastitis using hematoxylin and eosin(HE)staining,immunohistochemistry staining,and immunofluorescence staining.The findings provide insights into the pathogenesis and clinical treatment of granulomatous lobular mastitis. Methods:HE staining,immunohistochemistry for epidermal growth factor-like module-containing mucin-like hormone receptor-like 1(F4/80),and cluster of differentiation(CD)11c,as well as immunofluorescence staining were performed on sections of non-dilated ducts,dilated ducts,lesional lobules,and granulomatous foci from 28 patients diagnosed with granulomatous lobular mastitis at Dongzhimen Hospital of Beijing University of Chinese Medicine.Pathological features were analyzed,and macrophage counts were performed. Results:Immunohistochemical staining showed that CD11c-positive macrophages were clustered around dilated ducts and adjacent to affected lobules.However,their expression was less prominent around non-dilated ducts and granulomatous lesions with complete destruction of lobular structures,and granulomatous lesions with incomplete destruction of lobular structures,but their expression was less evident around non-dilated ducts.Immunofluorescence staining showed cells co-expressing F4/80 and CD11c in clusters around dilated ducts and affected lobules,while no expression was observed around non-dilated ducts and granulomatous foci. Conclusion:The pathogenesis of granulomatous lobular mastitis may involve a type Ⅳ hypersensitivity reaction triggered by impaired phagocytic function of macrophages within breast ducts.关键词
肉芽肿小叶性乳腺炎/表皮生长因子样结构含黏蛋白激素样受体1/巨噬细胞/淋巴细胞分化簇11c/乳腺导管Key words
granulomatous lobular mastitis/epidermal growth factor-like module-containing mucin-like hormone receptor-like 1/macrophages/cluster of differentiation 11c/mammary ducts引用本文复制引用
左禧萌,高翔,汪唐顺,高爽,史晓光..肉芽肿小叶性乳腺炎导管病理学特征[J].临床与病理杂志,2023,43(10):1786-1792,7.基金项目
北京中医药大学新教师创新项目(2021-BUCMXJKY001).This work was supported by the New Teacher Initiation Fund Project of Beijing University of Chinese Medicine,China(2021-BUCMXJKY001). （2021-BUCMXJKY001）
