临床与病理杂志2023，Vol.43Issue(10)：1809-1815,7.DOI:10.11817/j.issn.2095-6959.2023.230111
振源胶囊对慢性心力衰竭患者循环微粒的影响
Effect of Zhenyuan capsule on circulating microparticles in patients with chronic heart failure
摘要
Abstract
Objective:Circulating microparticles(MPs)play an important role in the cardiovascular system,while Zhenyuan capsules have unique advantages in the treatment of chronic heart failure(CHF).This study explores the changes in the content and function of MPs in CHF patients before and after taking Zhenyuan capsule. Methods:A total of 32 patients with CHF,who visited the Department of Cardiology at the Affiliated Hospital of Shaanxi University of Chinese Medicine from June 2018 to March 2019,were selected as research subjects.Fasting venous blood samples were collected from patients before and after 12 weeks of Zhenyuan capsule administration.MPs were extracted from the patient's blood,and their concentration and source were determined.Subsequently,the effects of MPs on the vasodilation function of isolated SD rat thoracic aorta and the expression of endothelial nitric oxide synthase(eNOS)and nitric oxide(NO)production were detected. Results:There was no statistically significant difference in the level of MPs in patients'blood before and after 12 weeks of Zhenyuan capsule administration(P>0.05).Zhenyuan capsules partially alleviated the impairment of vascular dilation function induced by MPs in isolated rat aortas.Additionally,Zhenyuan capsules partially inhibited the downregulation of eNOS and NO production in the isolated rat thoracic aorta induced by MPs(both P<0.05). Conclusion:Zhenyuan capsules may exert cardiovascular protective effects in CHF,partially by inhibiting the damage to endothelial function caused by MPs.关键词
慢性心力衰竭/循环微粒/一氧化氮/内皮功能Key words
chronic heart failure/circulating microparticles/nitric oxide/endothelial function引用本文复制引用
李文波,常凤军,王亚萍,杨禹娟,王群让,尤红俊..振源胶囊对慢性心力衰竭患者循环微粒的影响[J].临床与病理杂志,2023,43(10):1809-1815,7.基金项目
陕西省自然科学基金(2017JQ8025) （2017JQ8025）
陕西省分子心脏学重点实验室基金(KLMC-2018-05).This work was supported by the Shaanxi Province Natural Science Basic Research Project(2017JQ8025)and the Open Project Program of Key Laboratory of Molecular Cardiology of Shaanxi Province(KLMC-2018-05),China. （KLMC-2018-05）
