临床与病理杂志2023，Vol.43Issue(10)：1857-1864,8.DOI:10.11817/j.issn.2095-6959.2023.220009
脑部类淋巴系统中水通道蛋白4与脑出血
Aquaporin 4 and the glymphatic system in intracerebral hemorrhage
摘要
Abstract
The glymphatic system(GS)is a newly defined,brain-wide perivascular transport network between cerebrospinal fluid and interstitial solutes,promoting the clearance of metabolic waste from the brain.This complex network consists of the periarterial cerebrospinal fluid inflow pathway,astrocyte-mediated fluid and solutes convective transport supported by aquaporin 4(AQP4),and perivenous outflow pathway.Dysfunction of the GS is related to various neurological diseases and plays a crucial role in the pathological and physiological process of brain edema after intracerebral hemorrhage(ICH).Analyzing the relevant research on the brain GS and AQP4 in physiological and ICH conditions can provide further insights into their potential applications in risk assessment,diagnosis,prognosis,and treatment after ICH,as well as their relevance to traditional Chinese medicine theories,such as the'Xuanfu'theory in stroke.关键词
脑部类淋巴系统/水通道蛋白4/脑出血Key words
glymphatic system,brain/aquaporins 4/intracerebral hemorrhage引用本文复制引用
杨镇宇,张博,涂鄂文..脑部类淋巴系统中水通道蛋白4与脑出血[J].临床与病理杂志,2023,43(10):1857-1864,8.基金项目
湖南省重点研发项目(2020SK2122) （2020SK2122）
湖南省教育厅湖南省研究生科研创新项目(CX20220824).This work was supported by the Key Research and Development Projects of Hunan Province(2020SK2122)and the Innovation Platform Open Fund Project of Education Department of Hunan Province(CX20220824),China. （CX20220824）
