基于生物信息学与网络药理学分析薯蓣皂苷治疗阿尔茨海默病和新型冠状病毒肺炎的靶点研究OACSTPCD
Bioinformatics and network pharmacology identify the therapeutic role and potential targets of diosgenin in Alzheimer disease and COVID-19
目的:基于生物信息学、网络药理学及分子对接技术探究薯蓣皂苷治疗阿尔茨海默病(alzheimer disease,AD)和新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)的靶点.方法:利用生物信息学对AD和COVID-19的共有的差异表达基因(differential expression gene,DEGs)进行富集分析.接着,通过转录因子(transcription Factor,TF)调控网络分析,并利用…查看全部>>
Objective:To explore the targets of diosgenin in treatment of Alzheimer′s disease(AD)and Coronavirus Dis-ease 2019(COVID-19)based on bioinformatics,network pharmacology and molecular docking techniques.Methods:Differential expression genes(DEGs)shared by AD and COVID-19 were enriched by bioinformatics.Secondly,key genes in transcription fac-tor(TF)of AD and COVID-19 were found by analysis of regulatory networks,and Cytoscape was used to visualize the network…查看全部>>
张华雄;张明惠;李红燕
新疆维吾尔自治区人民医院 神经内科,新疆 乌鲁木齐 830000新奇康药业股份有限公司,新疆 乌鲁木齐 830000新疆维吾尔自治区人民医院 神经内科,新疆 乌鲁木齐 830000
中医学
生物信息学网络药理学薯蓣皂苷阿尔茨海默病新型冠状病毒肺炎
BioinformaticsNetwork pharmacologyDiosgeninAlzheimer's diseaseCOVID-19
《海南医学院学报》 2024 (1)
39-49,11
This study was supported by Research and Development and Industrialization Demonstration of Xinjiang Special Medicinal Materials,Antiinfective Drugs and Disinfection Products-Construction of Xinjiang Special Resource Antiinfective Drug Research and Development Platform(2021A03002-4) 新疆特色药材抗感染药物及消毒产品研发及产业化示范-新疆特色资源抗感染药物研发平台建设(2021A03002-4)
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