海南医学院学报2024，Vol.30Issue(1)：50-59,10.DOI:10.13210/j.cnki.jhmu.20230825.003
西药联合芪苈强心胶囊与单纯西药治疗慢性心力衰竭疗效比较的Meta分析
Meta analysis of the efficacy of western medicine combined with Qiliqiangxin capsule versus western medicine alone in the treatment of chronic heart failure
摘要
Abstract
Objective:To compare the clinical efficacy of conventional western medicine combined with Qiliqiangxin cap-sule and western medicine alone in the treatment of chronic heart failure,and to prove that Qiliqiangxin capsule combined treat-ment has more advantages,providing reference for clinical decision-making in the treatment of chronic heart failure.Methods:Ran-domized controlled trials(RCTs)of conventional western medicine treatment and western medicine combined with Qiliqiangxin capsule in the treatment of chronic heart failure were searched in databases such as PubMed,Embase,Web of science,CNKI,WanFang,VIP,and CBM.The bias risk assessment was conducted using the RCT tool recommended by Cochrane,and then the meta-analysis was performed using RevMan5.4 and Stata17 software.Compare the efficacy evaluation of cardiac function,left ven-tricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),cardiac stroke output(SV),6-minute walk-ing test(6MWT),and N-terminal proBNP in the conventional western medicine combined with Qiliqiangxin capsule group(here-inafter referred to as the treatment group)and the conventional western medicine group(hereinafter referred to as the control group).Results:A total of 20 RCTs meeting the criteria were included,including 2 953 patients,including 1 508 in the treatment group and 1 445 in the control group.The results of meta-analysis showed that the treatment group had significantly better cardiac function evaluation,LVEF,LVEDD,SV,6MWT,and NT-proBNP improvement than the control group.Its central functional efficacy evaluation(OR=2.09,95%CI:1.71-2.55,P<0.001),LVEF(WMD=7.05,95%CI:5.30-8.79,P<0.000 01),LVEDD(WMD=6.73,95%CI:3.18-10.29,P=0.000 2),SV(WMD=6.73,95%CI:3.18-10.29,P=0.000 2),6MWT(SMD=0.70,95%CI:0.54-0.87,P<0.000 01),NT-proBNP(SMD=-1.95,95%CI:-2.5 2--1.38(P<0.000 1),with statistically significant differences.Conclusion:Conventional western medicine combined with Qiliqiangxin capsule can significant-ly improve the clinical efficacy of heart failure,improve LVEF,LVEDD,SV,and NT-proBNP index,and improve exercise tol-erance.It is worth using for reference in the treatment.关键词
芪苈强心胶囊/心力衰竭/Meta分析/随机对照试验Key words
Qiliqiangxin capsule/Heart failure/Meta analysis/Randomized controlled trial分类
医药卫生引用本文复制引用
杨敏,卢健棋,庞延,周家谭,罗文宽..西药联合芪苈强心胶囊与单纯西药治疗慢性心力衰竭疗效比较的Meta分析[J].海南医学院学报,2024,30(1):50-59,10.基金项目
This study was supported by National Natural Science Foundation of China Regional Science Foundation Project(82160887) （82160887）
General Project of Guangxi Natural Science Foundation(2021GXNSFAA220111) （2021GXNSFAA220111）
Guangxi Natural Science Foundation Project Youth Science Foundation Project(2021GXNSFBA196018) 国家自然科学基金地区科学基金项目(82160887) （2021GXNSFBA196018）
广西自然科学基金项目面上项目(2021GXNSFAA220111) （2021GXNSFAA220111）
广西自然科学基金项目青年科学基金项目(2021GXNSFBA196018) （2021GXNSFBA196018）
