中医学报2024，Vol.39Issue(1)：77-83,7.DOI:10.16368/j.issn.1674-8999.2024.01.014
基于PI3K/AKT信号通路探讨中医药治疗肺癌研究进展
Research Progress in Traditional Chinese Medicine Treatment of Lung Cancer Based on PI3K/AKT Signaling Pathway
摘要
Abstract
The phosphatidylinositol3 kinase(PI3K)/protein kinase B(AKT)signaling pathway is one of the important signal trans-duction systems in organisms,which has various functions such as regulating cell growth,differentiation,and apoptosis,and is related to the proliferation,apoptosis,autophagy,invasion and metastasis,and epithelial-mesenchymal transformation of lung cancer cells trans-formation,EMT)and other cellular activities are closely related.Traditional Chinese medicine can regulate the expression of cyclins and apoptosis-related proteins by intervening in the PI3K/AKT pathway and its related target proteins,thereby inhibiting proliferation and inducing apoptosis.Promote autophagy in lung cancer cells by upregulating the expression of autophagy-related proteins;By down-regulating the expression of matrix-metalloproteinase(MMP),the invasion and metastasis ability of lung cancer cells was reduced.Re-versal of EMT and drug resistance through multiple targets and mechanisms.However,there are also many shortcomings in the research of traditional Chinese medicine in the treatment of lung cancer based on PI3K/AKT signaling pathway:(1)PI3K/AKT signaling path-way is crisscrossed with multiple pathways,and many studies have found that traditional Chinese medicine can affect the expression of multiple signaling pathways at the same time,but the interaction and interaction between these pathways have not been clarified.(2)The PI3K/AKT signaling pathway has a wide range of effects,and most studies have only confirmed that the anti-lung cancer effect of traditional Chinese medicine is correlated with the expression level of key proteins in the pathway,but there are few further studies on the mechanism of action.(3)Such studies are limited to cell experiments and animal experiments,and there is a lack of high-quality clinical controlled trials to validate.In the future,more clinical and basic research is needed to further explore the mechanism of action of TCM against lung cancer.关键词
肺癌/中医药/PI3K/AKT信号通路/机制研究Key words
lung cancer/Chinese medicine/PI3K/AKT signaling pathway/mechanistic study分类
中医学引用本文复制引用
张格松,蒋士卿..基于PI3K/AKT信号通路探讨中医药治疗肺癌研究进展[J].中医学报,2024,39(1):77-83,7.基金项目
河南省中医药科学研究专项课题项目(2019ZYZD06) （2019ZYZD06）
河南省自然科学基金项目(232300420055) （232300420055）
张仲景传承与创新专项课题项目(GZY-KJS-2022-038-2) （GZY-KJS-2022-038-2）
