中医学报2024，Vol.39Issue(1)：84-91,8.DOI:10.16368/j.issn.1674-8999.2024.01.015
中药基于PI3K/AKT/mTOR信号通路治疗膝骨关节炎
Traditional Chinese Medicine Treatment of Knee Osteoarthritis Based on PI3K/AKT/mTOR Signaling Pathway
摘要
Abstract
The phosphatidylinositol 3-kinase(PI3K)/protein kinase B(PKB/AKT)/mammalian rapamycin target protein(mTOR)signaling pathway plays a crucial role in the formation,development,and treatment of knee osteoarthritis(KOA),It plays an important role in cartilage proliferation and apoptosis,subchondral bone remodeling,and synovitis.Inhibiting PI3K/AKT/mTOR signaling can pro-mote autophagy,alleviate joint inflammation,and restore joint homeostasis;Activating PI3K/AKT/mTOR signaling can promote chondro-cyte proliferation and differentiation,and reduce apoptosis.Based on the PI3K/AKT/mTOR signaling pathway analysis of traditional Chinese medicine,this study focuses on the promotion of chondrocyte proliferation,reduction of apoptosis,inhibition of inflammatory re-sponse,enhancement of chondrocyte autophagy,restoration of joint homeostasis,and reduction of joint injury.The aim is to provide ideas for the clinical treatment and basic research of KOA.关键词
膝骨性关节炎/中药/PI3K/AKT/mTOR信号通路Key words
knee osteoarthritis/traditional Chinese medicine/PI3K/AKT/mTOR signaling pathway分类
医药卫生引用本文复制引用
王笑甜,陈唤楠,孙福平,周友龙..中药基于PI3K/AKT/mTOR信号通路治疗膝骨关节炎[J].中医学报,2024,39(1):84-91,8.基金项目
河南省特色骨干学科建设项目(STG-ZYX02-202115) （STG-ZYX02-202115）
