中医学报2024，Vol.39Issue(1)：210-215,6.DOI:10.16368/j.issn.1674-8999.2024.01.035
补肾活血膏联合隔药灸治疗肾虚血瘀型股骨头坏死
Treatment of Kidney Deficiency and Blood Stasis Type Femoral Head Necrosis with Kidney Tonifying and Blood Activating Oral Paste Combined with Medicinal Moxibustion
摘要
Abstract
Objective:To observe the effects of Bushen Huoxue Oral Paste combined with herbal moxibustion on pain,blood lipids,and hemorheology in patients with osteonecrosis of the femoral head(ONFH)of kidney deficiency and blood stasis syndrome.Method:95 patients with ONFH were randomly divided into a study group(n =48)and a control group(n =47).The control group was treated with Xianlinggubao Capsules and Alendronate Sodium Tablets,while the study group was treated with Bushen Huoxue Oral Paste and herbal moxibustion.Compare the traditional Chinese medicine syndrome scores,visual analogue scale(VAS),hip Harris score,and blood lipids[total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),and triglycerides(TG)]between two groups of patients before and after treatment Hemorheology[whole blood viscosity,plasma viscos-ity(PV),red blood cell aggregation index(Arbe),red blood cell electrophoresis time(EPT),red blood cell deformation index(TK)]and clinical efficacy.Results:(1)The effective rate of the study group was 91.67%,while that of the control group was 72.34%.The difference between the two groups was statistically significant(P＜0.05).(2)After treatment,the VAS scores of both groups of pa-tients were significantly lower than before treatment in this group(P＜0.05);The VAS score of the research group was(1.92±0.71),lower than that of the control group during the same period(P＜0.05).(3)After treatment,the Harris scores of the hip joints in both groups of patients were significantly higher than before treatment in this group;The Harris score of the hip joint in the research group was(88.33±8.11)points,which was higher than that of the control group during the same period(P＜0.05).(4)After treat-ment,the serum TC,TG,and LDL-C of both groups of patients were lower than before treatment.The serum TC of the study group was(5.11±0.68)mmol·L-1,TG was(1.43±0.42)mmol·L-1,and LDL-C was(2.33±0.71)mmol·L-1,all lower than that of the control group during the same period(P＜0.05).(5)After treatment,the whole blood viscosity,PV,Arbe,EPT,and TK of both groups of patients were lower than before treatment.In the study group,the whole blood viscosity(200 s-1)was(3.67±0.37)mPa·s-1,the whole blood viscosity(30 s-1)was(4.88±0.58)mPa·s-1,the whole blood viscosity(3 s-1)was(6.29±1.48)mPa·s-1,the PV was(1.43±0.62)mPa·s-1,the Arbe was(5.01±1.14),the EPT was(13.18±3.48)s,and the TK was(0.61).4±0.06),all lower than the control group during the same period(P＜0.05).(6)No serious adverse events were ob-served in both groups.Conclusion:The combination of Bushen Huoxue Oral Paste and herbal moxibustion has a significant therapeutic effect on ONFH patients with kidney deficiency and blood stasis syndrome.It can effectively alleviate pain,improve hip joint function,improve blood lipids and hemorheological indicators,and has high safety.关键词
股骨头坏死/肾虚血瘀证/补肾活血膏/隔药灸/疼痛/血液流变学Key words
femoral head necrosis/Kidney deficiency and blood stasis syndrome/Bushen Huoxue Oral Paste/medicinal moxibustion/pain/hemorheology分类
医药卫生引用本文复制引用
朱紫燕,阎晓霞..补肾活血膏联合隔药灸治疗肾虚血瘀型股骨头坏死[J].中医学报,2024,39(1):210-215,6.基金项目
河南省中医药科学研究专项课题项目(20-21ZY1026) （20-21ZY1026）
