集成技术2024，Vol.13Issue(1)：106-116,11.DOI:10.12146/j.issn.2095-3135.20230213001
在体全眼微血流超声超分辨成像
In Vivo Whole Eye Microvasculature Imaging with Ultrasound Localization Microscopy
摘要
Abstract
The early stage of many ophthalmic diseases is usually accompanied by morphological and hemodynamic changes of microvessles.Thus,evaluation of the whole eye microvessels plays an important role in the comprehensive diagnosis of ophthalmic diseases.Due to the limited penetration depth of optical imaging techniques,especially in the case of low transmittance of the medium,it is difficult for existing optical imaging techniques to visualize the microvessels of the entire eye.For this purpose,this paper developed an ultrasound super-resolution imaging technique that can visualize the whole eye three-dimensional microvascular system with micron resolution.Specifically,a linear array with a central frequency of 10 MHz was used to rapidly acquire multi-frame sequences,and then a super-resolution image of a slice was obtained through microbubble signal extraction,localization,tracking and center point superposition.All the acquired slices were reconstructed into three-dimensional full-eye super-resolution microvascular images.In vivo experiment demonstrates that ultrasound localization microscopy(ULM)can visualize the microvascular system of the entire eye,which is important for early diagnosis of ophthalmic diseases.关键词
眼睛微血流/超分辨成像/机械扫描/微泡/超声Key words
ocular microvasculature/super resolution/mechanical scanning/microbubble/ultrasound分类
通用工业技术引用本文复制引用
张昌露,雷爽,刘佳妹,商东庆,马腾..在体全眼微血流超声超分辨成像[J].集成技术,2024,13(1):106-116,11.基金项目
国家自然科学基金项目(81827807) （81827807）
深圳市孔雀计划项目(KQTD20170810160424889) （KQTD20170810160424889）
中国科学院科学仪器基金项目(YJKYYQ20190077) （YJKYYQ20190077）
深圳市超声成像与治疗重点实验室项目(ZDSYS20180206180631473) This work is supported by National Natural Science Foundation of China(81827807),Shenzhen Peacock Plan(KQTD20170810160424889),Scientific Instruments Funding of Chinese Academy of Sciences(YJKYYQ20190077),and Shenzhen Key Laboratory of Ultrasound Imaging and Therapy(ZDSYS20180206180631473) （ZDSYS20180206180631473）
