中国当代医药2023，Vol.30Issue(36)：67-71,5.
维生素C辅助治疗脓毒症的效果
Effect of vitamin C in the adjuvant treatment of sepsis
摘要
Abstract
Objective To explore the effect of vitamin C in the adjuvant treatment of sepsis.Methods A total of 80 patients with sepsis admitted to Intensive Care Unit of Xiamen Humanity Hospital Affiliated to Fujian Medical University from Jan-uary 2021 to October 2022 were selected as research subjects.They were divided into vitamin C group(40 cases)and the control group(40 cases)according to the random number table method.All patients underwent the symptomatic supportive treatments such as routine anti-infection,fluid resuscitation and mechanical ventilation.Besides,vitamin C was intra-venously pumped in vitamin C group,and an equal dose of glucose was pumped intravenously in the control group.The cu-rative effect,inflammation indicators,oxidative stress indicators and prognosis in the two groups were compared.Results After seven days of treatment,total effective rate of treatment in vitamin C group was higher than that in the control group,and the difference was statistically significant(P＜0.05).Before treatment,procalcitonin(PCT),tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and IL-8 levels of two groups were compared,the differences were not statistically significant(P＞0.05).After treatment,the levels of PCT,TNF-α,IL-6 and IL-8 of two groups were lower than those before treatment,and vitamin C group was lower than the control group,and the differences were statistically significant(P＜0.05).Before treatment,superoxide dismutase(SOD)and malondialdehyde(MDA)levels of two groups were compared,the differences were not statistically significant(P＞0.05).After treatment,SOD levels in the two groups were higher than those before treatment,MDA levels in the two groups were lower than those before treatment,and SOD level in vitamin C group was higher than that in the control group,while MDA level in vitamin C group was lower than that in the control group,and the differences were statistically significant(P＜0.05).Before treatment,acute physiology and chronic health evaluation scoring systemⅡ(APACHEⅡ)and sepsis-related organ failure assessment(SOFA)of two groups were compared,the differences were not statistically significant(P＞0.05).After treatment,APACHEⅡand SOFA scores in two groups were lower than those before treatment,and the scores of vitamin C group were lower than those that of the control group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in the 28 day mortality rate between the two groups(P＞0.05).Conclusion Vitamin C in the adjuvant treatment of sepsis can improve clinical effi-cacy,control inflammation and oxidative stress levels in the body,and improve patient prognosis.关键词
维生素C/脓毒症/疗效/预后/炎症/氧化应激Key words
Vitamin C/Sepsis/Curative effect/Prognosis/Inflammation/Oxidative stress分类
临床医学引用本文复制引用
王国华,肖海平,黄婷婷,张毅..维生素C辅助治疗脓毒症的效果[J].中国当代医药,2023,30(36):67-71,5.基金项目
福建省厦门市医疗卫生指导性项目(3502Z20224ZD1112). （3502Z20224ZD1112）
