吉林大学学报（理学版）2024，Vol.62Issue(1)：174-180,7.DOI:10.13413/j.cnki.jdxblxb.2023274
利用Markov模型研究Aβ突变体的构象转变过程
Using Markov Model to Study Conformational Transformation Process of Aβ Mutant
摘要
Abstract
In order to suppress the transformation of amyloid β polypeptide(Aβ)from random curling or α-helix to β-folding structure,we studied the conformational changes of wild type Aβ and its array mutants.Combining Markov model and molecular dynamics simulation,we studied the conformational change precess of the wild type,A4 type and D7N type Aβ,and identified the conformational transformation path of three Aβ types.The experimental results show that one region of β-folding is found in the wild type Aβ,and the conformation of the A4 type Aβ is almost unchanged,while two regions of β-folding are found in the D7N type Aβ,indicating that the D7N type mutant has the characteristic of promoting β-folding.The results provide a theoretical baisis for exploring treatment methods for Alzheimer's disease.关键词
阿尔兹海默症/淀粉样β多肽/分子动力学模拟/Markov模型Key words
Alzheimer's disease/amyloid β polypeptide/molecular dynamics simulation/Markov model分类
生物科学引用本文复制引用
姚星宇,刘璎锐,韩葳葳,万由衷..利用Markov模型研究Aβ突变体的构象转变过程[J].吉林大学学报（理学版）,2024,62(1):174-180,7.基金项目
吉林省科技厅计划发展项目(批准号:20230204044YY). （批准号:20230204044YY）
