军事医学2023，Vol.47Issue(12)：951-955,5.DOI:10.7644/j.issn.1674-9960.2023.12.012
HK2在肿瘤进展及产生耐药机制中的作用研究进展
Research progress in roles of HK2 in tumor progression and mechanism of drug resistance
摘要
Abstract
Hexokinase(HK),as the first rate-limiting enzyme for glycolysis,promotes tumor progression by improving levels of aerobic glycolysis in tumor cells.By binding to the voltage-dependent anion channel(VDAC)on the outer mitochondrial membrane,HK2 is involved in increasing the stability of mitochondrial membranes,thereby inhibiting apoptosis of tumor cells and promoting tumor survival,which is why HK2 may be one of the factors that promote tumor resistance to chemotherapy drugs.This article reviews the research progress in the role of HK2 in tumor glucose metabolism,mitochondrial apoptosis and drug resistance.关键词
己糖激酶2/有氧糖酵解/线粒体凋亡/耐药Key words
hexokinase/aerobic glycolysis/mitochondrial apoptosis/tumor resistance分类
医药卫生引用本文复制引用
谢世顺,李相军,石少敏..HK2在肿瘤进展及产生耐药机制中的作用研究进展[J].军事医学,2023,47(12):951-955,5.基金项目
吉林省自然科学基金项目(省联合基金白求恩医学专项)(20200201610JC) （省联合基金白求恩医学专项）
