检验医学与临床2024，Vol.21Issue(1)：16-19,4.DOI:10.3969/j.issn.1672-9455.2024.01.004
DTT在D-二聚体假性增高病例中的应用
Application of DTT in cases with D-dimer pseudo elevation
摘要
Abstract
Objective To investigate the situation of dithithreitol(DTT)in correcting the D-dimer abnor-mal results in 19 patients with plasma D-dimer level＞fibrin and fibrinogen degradation product(FDP)level.Methods The specimens of 19 patients who firstly appeared plasma D-dimer level＞FDP level visited in this hospital from January 2022 to March 2023 were collected as the experimental group,and were tested by dilu-tion and comparison tests to determine whether being D-dimer pseudo elevation.Meanwhile,20 cases of 1:9 sodium citrate anticoagulated plasma with FDP/D-dimer ratio of 2-5 were randomly selected as the control group,the DTT correction test and normal saline treatment test were performed on both the experimental group and control group,then the related data conducted the analysis.Results As the dilution multiple in-crease,the D-dimer levels in the 19 cases showed the decreasing trend(P＜0.05),while FDP had no signifi-cant change(P＞0.05).By changing the system detection,all 19 cases could be corrected as the FDP level＞D-dimer level.After the DTT treatment in the control group,there was no statistically significant change in the D-dimer level compared to saline treatment(P＞0.05).In the experimental group,there was statistically significant differences between the DTT treatment results and saline treatment results.After the DTT treat-ment,15 cases were corrected as the FDP level＞D-dimer level,moreover there was no statistical difference between the DTT corrected results and the comparison system results(P＞0.05).Conclusion In this study,most individuals of the D-dimer pseudo elevation can be corrected after the DTT pretreatment,showing con-sistency between the corrected results and those of the comparison system.关键词
D-二聚体/假性增高/干扰/二硫苏糖醇/纤维蛋白(原)降解产物Key words
D-dimer/pseudo elevation/interference/dithiothreitol/fibrin and fibrinogen degrada-tion product分类
医药卫生引用本文复制引用
乔莹利,李涛,宋迪,张垒,许泼实..DTT在D-二聚体假性增高病例中的应用[J].检验医学与临床,2024,21(1):16-19,4.基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20200119,LHGJ20200081). （LHGJ20200119,LHGJ20200081）
