ERAT与LA治疗成人急性无并发症性阑尾炎疗效及安全性的Meta分析OACSTPCD

Objective To compare the differences in the efficacy and safety between endoscopic retrograde appendicitis therapy(ERAT)and laparoscopic appendectomy(LA)in the treatment of adult acute non-com-plication appendicitis.Methods The databases of PubMed,Cochrane Library,Web of Science,Embase,Chi-nese Biomedical Literature Database(SinoMed),China National Knowledge Infrastructure(CNKI),Wanfang Database and Chinese Science Journal Database were retrieved for the randomized controlled trials(RCT)and retrospective studies of ERAT versus LA in the treatment of adult acute non-complication appendicitis from the date of their establishment to December 1,2022.The Meta analysis on the final statistical data was per-formed by using RevMan5.3 software.The heterogeneity was assessed by using the statistic I2.The odds ratio(OR),weighted mean difference(WMD)for 95％confidence intervals(CI)were calculated by using fixed effects or random effects models.Results The operation time(WMD=-19.46,95％CI:-27.36 to-11.55,P＜0.001),time of postoperative body temperature recovery to normality(WMD=-0.92,95％CI:-1.13 to-0.71,P＜0.001),time of WBC count to normality(WMD=-1.79,95％CI:-2.55 to-1.02,P＜0.001),postoperative continuous bed rest time(WMD=-1.77,95％CI:-2.34 to-1.20,P＜0.001)and postoperative duration of hospital stay(WMD=-2.77,95％CI:-3.63 to-1.91,P＜0.001)in the ERAT group were shorter than those in the LA group,moreover the incidence rate of complications(OR=0.26,95％CI:0.12 to 0.54;P=0.000 3)was lower.Conclusion ERAT is superior to LA in the treatment of adult acute non-complicationappendicitis.It not only reduces the pain of the patients,saves the medical resources,but also preserves the biological function of the appendix,which has great value of clinical promotion and application.