摘要
Abstract
Objective To explore the effect of digital technology coordinated with model making implant guide plate implantation repair surgery on the local inflammation,oxidative stress response and pain mediators levels after oral implantation in elderly patients with dentition defects.Methods A total of 101 elderly pa-tients with dentition defects admitted and treated in this hospital from February 2021 to May 2022 were se-lected as objects,excluding 8 cases of losing follow up,and 93 cases were finally included.They were divided into the study group(48 cases)and control group(45 cases)by using the random number table method.The control group adopted the conventional turning over flap implantation,while the study group received the dig-ital technology coordinated with model making implant guide plate implantation repair surgery.The pain me-diators in the gingival crevicular fluid[histamine(HIS),prostaglandin E2(PEG2),substance P(SP),bradyki-nin(BK)]before operation and on postoperative 3 d were detected by the enzyme linked immunosorbent as-say.The oxidative stress molecules[nicotinamide adenine dinucleotide phosphate oxidase 2(NOX2),NOX4,nuclear factor E2 related factor 2(NRF2).antioxidant response element(ARE)]and the inflammatory signal molecules[NOD-like receptor protein 3(NLRP3),nuclear transcription factor-κB(NF-κB),toll-like receptor 4(TLR4),apoptosis-related dot-like protein(ASC),caspase-1(Caspase-1)]expression levels were calculat-ed.The follow-up of the patients lasted for 1 year.The operation and postoperative recovery were compared a-mong the all subjects.Results The HIS,PEG2,SP and BK levels on postoperative 3 d in the both groups in-creased significantly(P＜0.01),but those in the study group were lower than those in the control group(P＜0.01);the NF-κB,TLR4,NLRP3,ASC and Caspase-1 expression levels in the both groups increased signifi-cantly(P＜0.01),but those in the study group were lower than those in the control group(P＜0.01);the NOX2,NOX4,NRF2,and ARE expression levels in the two groups increased significantly(P＜0.01),but those in the study group were lower than those in the control group(P＜0.01).After one year follow-up,the incidence rate of complications in the study group was 2.08％,which was significantly lower than 20.00％in the control group,and the difference between the two groups was statistically significant(P＜0.05).Conclu-sion The digital technology coordinated with model making implant guide plate implantation repair surgery could significantly reduce the local inflammation and oxidative stress caused by oral implantation in elderly pa-tients with dentition defects,the pain is lighter and the stability of the implant after surgery is better.关键词
数字化技术/模型制作种植导板种植修复术/牙列缺损/口腔种植/炎症应激反应/疼痛介质/老年Key words
digital technology/model making implant guide plate implantation repair surgery/denti-tion defect/oral implant/inflammatory stress response/pain mediator/elderly分类
医药卫生
