摘要
Abstract
Objective To study the effects of somatostatin combined with low molecular heparin on the blood hypercoagulability,procalcitonin(PCT),C-reactive protein(CRP)and renin-angiotensin-aldosterone system(RAAS)in the patients with hyperlipidemic acute pancreatitis(HLAP).Methods A total of 66 pa-tients with HLAP admitted and treated in Baofeng Branch Hospital of Pingdingshan Municipal Second People's Hospital from January 2020 to January 2023 were selected as the research subjects and divided into the refer-ence group(33 cases)and combination group(33 cases)according to the treatment regimen.The reference group was treated with somatostatin,and the combination group was treated with somatostatin combined with low molecular weight heparin.The clinical efficacy,improvement time of clinical symptoms,hemorheology in-dexes(red blood cell aggregation index,plasma viscosity,whole blood low tangential viscosity,whole blood high tangential viscosity)before and after treatment,serum RAAS indexes[angiotensin-Ⅱ(Ang-Ⅱ),renin(E),aldosterone(ALD)],serum PCT,CRP,heat shock protein 70(HSP70)and heat shock protein 27(HSP27)were compared between the two groups.Results The total effective rate of the combination group was higher than that of the reference group(96.97％vs.75.76％),and the difference was statistically signifi-cant(P＜0.05).The recovery time of intestinal function,time of blood amylase recovering to normality and disappearance time of peritonitis signs and abdominal pain in the combination group were shorter than those in control group,and the differences were statistically significant(P＜0.05).After treatment,the decrease ran-ges of red cell aggregation index,whole blood low tangential viscosity,whole blood high tangential viscosity and plasma viscosity in the combination group were greater than those in the reference group,and the differ-ences were statistically significant(P＜0.05).After treatment,the serum E,Ang-Ⅱ and ALD levels in the combination group were lower than those in the reference group,and the differences were statistically signifi-cant(P＜0.05).Compared with before treatment,the levels of serum PCT,CRP,HSP70 and HSP27 after treatment in all groups were significantly decreased,which in the combination group was more significant,and the differences were statistically significant(P＜0.05).Conclusion Somatostatin combined with low molecu-lar heparin is effective in the treatment of HLAP,which can improve the blood hypercoagulable state,reduce the inflammation reaction and help patients recover from the disease.关键词
生长抑素/低分子肝素/高脂血症性急性胰腺炎/红细胞聚集指数/C反应蛋白Key words
somatostatin/low molecular heparin/hyperlipidemic acute pancreatitis/red blood cell aggregation index/C-reactive protein分类
医药卫生
