摘要
Abstract
Objective To study the effect of Xingnaojing combined with ribavirin in treating the children patients with viral encephalitis(VE).Methods A total of 124 children patients with VE admitted and treated in this hospital from December 2020 to February 2023 were divided into the reference group and study group according to the random number table method,62 cases in each group.The reference group was treated with ribavirin on the basis of conventional therapy,and the study group was treated with Xingnaojing on the basis of the reference group.The clinical efficacy,symptom disappearance time,neurological factor levels before and after treatment[nerve growth factor(NGF),neuron-specific enolase(NSE),brain-derived neurotrophic factor(BDNF),myelin basic protein(MBP)],plasma cell parameters[helper T cell 17(Th17)/regulatory T cell(Treg),the proportion of Treg,the proportion of Th17,microRNA-125b(miR-125b)]and inflammatory fac-tor levels[transforming growth factor-β(TGF-β),interleukin(IL)-17,tumour necrosis factor-a(TNF-a),IL-6]and the total incidence rate of adverse reactions were compared between the two groups.Results The total clinical efficiency of the study group was higher than that of the reference group(91.94％vs.77.42％,P＜0.05),and the difference was statistically significant;the disappearance time of clinical symptoms after treat-ment in the study group was shorter than that of the reference group(P＜0.05);the levels of NGF,MBP and NSE after treatment in the study group were lower than those in the reference group,while BDNF level was higher than that in the reference group,the differences were statistically significant(P＜0.05);the proportion of Th17,miR-125b level and Th17/Treg after treatment in the study group were lower than those in the refer-ence group,while the proportion ofTreg was higher than that in the reference group,and the differences were statistically significant(P＜0.05).The TNF-a,IL-6 and IL-17 levels after treatment were lower than those in the reference group,while the TGF-β level was higher than that in the reference group,and the differences were statistically significant(P＜0.05);the total incidence rate of adverse reactions had no statistical differ-ence between the two groups(P＞0.05).Conclusion Xingnaojing combined with ribavirin has significant effect in treating VE,could improve the neurological function and clinical symptoms,reduce the inflammatory response,increase the immune function,and the medication safe and reliable.关键词
神经生长因子/神经元特异性烯醇化酶/醒脑静/利巴韦林/T细胞/病毒性脑炎Key words
nerve growth factor/neuron-specific enolase/Xingnaojing/ribavirin/T cells/viral encephalitis分类
医药卫生
