摘要
Abstract
Objective To investigate the effects of escitalopram combined with mirtazapine on the cognitive function and serum neuron-specific enolase(NSE)and 3-methyl-4-hydroxyphenylate glycol(MHPG)levels in elderly patients with depression.Methods A total of 102 elderly patients with depression admitted and treated in this hospital from January 2021 to January 2023 served as the research subjects and divided into the combi-nation group and control group by the random number table method,51 cases in each group.The control group was treated with escitalopram,and the combination group was treated with escitalopram combined with mirtazapine.The clinical efficacy,Hamilton Depression Scale(HAMD)score,the Chinese version of the Montreal Cognitive Assessment Scale(MoCA)score,Pittsburgh Sleep Quality Index(PSQI)score,P300 e-vent-related potential(amplitude,latency),serum neurotransmitters[NSE,MHPG and homovanillic acid(HVA)]levels before and in 4 weeks after treatment and incidence rates of adverse reactions were compared between the two groups.Results The total effective rate in the combination group was 92.16％,which was higher than 76.47％in the control group(P＜0.05).After the 4-week treatment,the HAMD and PSQI scores in the combination group were lower than those in the control group,the MoCA score was higher than that in control group,and the differences were statistically significant(P＜0.05).After the 4-week treatment,the P300 latency in the combination group was shorter than that in the control group,the P300 amplitude was higher than that in the control group,and the differences were statistically significant(P＜0.05).After the 4-week treatment,the serum NSE level in the combination group was lower than that in the control group,while the MHPG and HVA levels were higher than those in the control group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in the total incidence rates of adverse reactions between the combined group and control group(11.76％vs.7.84％,P＞0.05).Conclusion The treatment of escitalopram combined with mirtazapine in elderly patients with depression could effectively en-hance the cognitive function,relieve the depressive symptoms and sleep disorders,and increase the treatment effect,moreover which has certain safety.关键词
艾司西酞普兰/米氮平/抑郁/神经元特异性烯醇化酶/3-甲基-4羟苯乙二醇Key words
escitalopram/mirtazapine/depression/neuron-specific enolase/3-methyl-4-hydroxy-phenylate glycol分类
医药卫生
