摘要
Abstract
Objective To explore the effects of dydrogesterone combined with letrozole for treating poly-cystic ovary syndrome(PCOS)on the inflammatory factors,serum dehydroepiandrosterone sulfate(DHEAS)and sex hormone binding globulin(SHBG).Methods A total of 84 patients with PCOS admitted and treated in this hospital from January 2020 to January 2021 were selected and randomly divided into the observation group and control group with 42 cases in each group.On the basis of oral metformin tables,the control group was treated with letrozole,and the observation group was treated with dydrogesterone on the above basis.Af-ter 12 menstrual cycles of treatment,the clinical efficacy was compared between the two groups.The sex hor-mones levels,ovulation situation,inflammatory factors,serum DHEAS and SHBG levels before and after treatment were compared between the two groups.The pregnancy status within 6 months after treatment fin-ish was compared between the two groups.The occurrence situation of adverse reactions during the treatment period was compared between the two groups.Results After treatment finished,the clinical efficacy of the observation group was better than that of the control group(P＜0.05).After treatment,the estradiol(E2),luteinizing hormone(LH),DHEAS,serum tumor necrosis factor-a(TNF-a)and interleukin(IL)-6 were de-creased compared with those before treatment,moreover the observation group was lower than the control group,and the differences were statistically significant(P＜0.05).The follicle-stimulating hormone(FSH),number of mature follicles,ovulation number and SHBG level after treatment in the two groups were in-creased compared with those before treatment,moreover the observation group was higher than the control group,and the differences were statistically significant(P＜0.05);the pregnancy rate in 6 months after the treatment finish in the observation group was higher than that in the control group(P＜0.05).There was no signifi-cant difference in the incidence of total adverse reactions between the two groups(P＞0.05).Conclusion Dydrogest-erone combined with letrozole in the treatment of PCOS could effectively inhibit the level of inflammatory fac-tors in the body,improve its clinical symptoms,correct the disorder of sex hormone secretion,promote ovula-tion,and increase the pregnancy rate of the patients,with high safety and obvious clinical effect,which is wor-thy of promotion and application.关键词
地屈孕酮/来曲唑/多囊卵巢综合征/硫酸脱氢表雄酮/性激素结合球蛋白Key words
dydrogesterone/letrozole/polycystic ovary syndrome/dehydroepiandrosterone sulfate/sex hormone binding globulin分类
医药卫生
