摘要
Abstract
Objective To explore the efficacy of lithium carbonate combined with magnesium valproate in the treatment of bipolar disorder manic episode and its effect on serum brain-derived neurotrophic factor(BD-NF)and cognitive function.Methods A total of 120 patients with bipolar disorder manic episode diagnosed in Baoshan District Mental Health Center from April 2021 to April 2023 were divided into the control group and observation group by the random number table method,60 cases in each group.The control group was treated with lithium carbonate,and the observation group was added with magnesium valproate on the basis of control group.The treatment efficacy,serum BDNF level,strongness and weakness of cognitive function and the Pikelafansen Mania Scale(BRMS)score before and after treatment were compared between the two groups.The adverse reactions occurrence was observed in the two groups.Results The total effective rate in the ob-servation group was 93.33％,which was higher than 70.00％in the control group(X2=5.454,P=0.020).After treatment,the BDNF level of the two groups increased,and the BDNF level of the observation group was higher than that of the control group,and the differences were statistically significant(P＜0.05).After the 4 weeks treatment,BRMS scores in the two groups were lower than those before treatment,the observa-tion group was significantly lower than the control group,and the differences were statistically significant(P＜0.05).The scores of Wisconsin Tablet Classification Test(WC-ST),verbal memory test(VLT-R)and continuous operation test(CPT)after treatment in the two groups were higher than those before treatment,moreover the observation group was significantly higher than the control group,and the differences were sta-tistically significant(P＜0.05).The total occurrence rates of adverse reactions had no statistical difference be-tween the two groups(X2=1.294,P=0.706).Conclusion Lithium carbonate combined with magnesium val-proate has good effect in treating bipolar disorder,not only effectively improves the manic symptoms,but also increases serum BDNF level and cognitive function scores.关键词
双相情感障碍/躁狂发作/丙戊酸镁/碳酸锂/脑源性神经营养因子/认知功能Key words
bipolar disorder/manic episode/magnesium valproate/lithium carbonate/brain-de-rived neurotrophic factor/cognitive function分类
医药卫生
