检验医学与临床2024，Vol.21Issue(1)：103-106,112,5.DOI:10.3969/j.issn.1672-9455.2024.01.024
冠心病患者血清Lp-PLA2、VEGF、S100-β水平与冠状动脉病变程度的关系研究
Relationship between serum Lp-PLA2,VEGF and S100-β levels with coronary vessel lesion degree in patients with coronary heart disease
邹辉鑫 1杜伟鹏 1翟素平 1闫彬 1胡天喜 1王海洋2
作者信息
- 1. 河南省南阳市中心医院医学检验科,河南南阳 473000
- 2. 河南省南阳市中心医院心血管内科,河南南阳 473000
- 折叠
摘要
Abstract
Objective To investigate the relationship between serum lipoprotein-associated phospholipase A2(Lp-PLA2),vascular endothelial growth factor(VEGF)and central nervous specific protein(S100-β)lev-els with coronary vessel lesion degree in the patients with coronary heart disease(CHD).Methods A total of 126 cases of CHD admitted and treated in the this hospital from March 2022 to February 2023 were selected as the CHD group,and 102 healthy subjects underwent the physical examination in this hospital during the same period were selected as the control group.The differences in the Lp-PLA2,VEGF,S100-β levels were com-pared between the CHD group and the control group and among the patients with different degrees of coro-nary vessel lesion in the CHD group.The receiver operating characteristic(ROC)curve was adopted to ana-lyze the value of Lp-PLA2,VEGF and S100-β for diagnosing CHD.Results The serum Lp-PLA2,VEGF and S100-β levels in the CHD group were higher than those in the control group,and the difference was statistical-ly significant(P＜0.05);the serum Lp-PLA2,VEGF and S100-β levels in the patients with different degrees of coronary vessel lesion in the CHD group were increased with the increase of coronary artery lesion degree(P＜0.05).The ROC curve analysis results showed that the sensitivity and specificity of the Lp-PLA2 single detection for diagnosing CHD were 78.8％and 93.3％,respectively,and the area under the curve(AUC)was 0.913(95％CI:0.522-0.974),which was superior to the single detection of S100-β(Z=2.289,P＜0.05).The sensitivity and specificity of the 3 indexes combined detection were 74.1％and 93.5％,respectively,AUC was 0.921(95％CI:0.812-0.979),which was better than the single detection of VEGF and S100-β,and the difference was statistically significant(Z=1.936,2.361,P＜0.05).Conclusion The serum Lp-pLA2,VEGF and S100-β levels in the patients with CHD are higher than those in the healthy people.The single and com-bined detection of these three indexes has a certain auxiliary reference value in diagnosing CHD.关键词
脂蛋白相关磷脂酶A2/血管内皮生长因子/中枢神经特异性蛋白/冠心病/诊断Key words
lipoprotein-associated phospholipase A2/vascular endothelial growth factor/central nerve specific protein/coronary heart disease/diagnosis分类
医药卫生引用本文复制引用
邹辉鑫,杜伟鹏,翟素平,闫彬,胡天喜,王海洋..冠心病患者血清Lp-PLA2、VEGF、S100-β水平与冠状动脉病变程度的关系研究[J].检验医学与临床,2024,21(1):103-106,112,5.
