检验医学与临床2024，Vol.21Issue(1)：123-125,130,4.DOI:10.3969/j.issn.1672-9455.2024.01.028
血清IL-22及CA19-9水平与结肠癌患者术后淋巴结转移的关系研究
Relationship between serum IL-22 and CA19-9 levels with postoperative lymph node metastasis in patients with colon cancer
季国国 1杨建军 2提海梅3
作者信息
- 1. 上海市金山区亭林医院外科,上海 201505
- 2. 上海市第五人民医院精神科,上海 200240
- 3. 上海市金山区亭林医院门诊护理部,上海 201505
- 折叠
摘要
Abstract
Objective To study the relationship between serum interleukin-22(IL-22)and peripheral blood glucose chain antigen19-9(CA19-9)with the postoperative lymph node metastasis in the patients with colon cancer.Methods A total of 112 patients with colon cancer admitted and treated in the Jinshan District Tinglin Hospital from January 2021 to January 2023 were selected as the study subjects.Among them,26 cases of co-lon cancer with lymph node metastasis were classified as the metastasis group,and 86 patients with colon cancer without lymph node metastasis were classified as the non-metastasis group.The baseline data were compared between the two groups.The serum IL-22 and CA19-9 levels were detected and compared between the two groups.The value of serum IL-22 and CA19-9 for predicting the lymph node metastasis in the patients with colon cancer was evaluated by the receiver operating characteristic(ROC)curve.The multivariate Logis-tic regression was adopted to analyze the influencing factors of lymph node metastasis occurrence in the pa-tients with colon cancer.Results There was no statistically significant difference in the TNM staging and tumor differentiation degree between the metastasis group and non-metastasis group(P＞0.05).The serum IL-22 and CA19-9 levels in the metastasis group were higher than those in the non-metastasis group,and the difference was statistically significant(P＜0.05).The ROC curve analysis found that the areas under the curves of serum IL-22 and CA19-9 predicted lymph node metastasis in the patients with colon cancer were 0.840 and 0.852,respectively.The multivariate Logistic regression analysis results showed that serum IL-22＞30.834 pg/mL and CA19-9＞45.115 U/mL were the risk factors for the lymph node metastasis occur-rence in the patients with colon cancer(P＜0.05).Conclusion The increase of serum IL-22 and CA19-9 lev-els are the risk factors for postoperative lymph node metastasis in the patients with colon cancer.In clinical practice,serum IL-22 and CA19-9 levels could serve as the markers in the auxiliary assessment of the lymph node metastasis risk in the patients with colon cancer.关键词
白细胞介素-22/糖链抗原19-9/淋巴结转移/结肠癌/关系Key words
interleukin-22/chain antigen19-9/lymph node metastasis/colon cancer/relationship分类
医药卫生引用本文复制引用
季国国,杨建军,提海梅..血清IL-22及CA19-9水平与结肠癌患者术后淋巴结转移的关系研究[J].检验医学与临床,2024,21(1):123-125,130,4.
