临床小儿外科杂志2023，Vol.22Issue(12)：1109-1113,5.DOI:10.3760/cma.j.cn101785-202310011-003
经导管动脉栓塞术治疗肝母细胞瘤破裂的初步探索
Preliminary exploration of transcatheter arterial embolization for ruptured hepatoblastoma
摘要
Abstract
Objective To explore the application of transcatheter arterial embolization(TAE)for rup-tured hepatoblastoma(HB).Methods From March 2021 to May 2023,clinical characteristics,laboratory exami-nations,imaging features and outcomes were retrospectively reviewed for 10 children with ruptured HB undergoing TAE.Results There were 1 boyand9 girls with a median onset age of 21.5(13.3,45.3)months.The medi-an tumor diameter at diagnosis was 13.0(10.8,15.3)cm.Alpha fetoprotein(AFP)was elevated at an initial diagnosis.And the median value of AFP was 443641(137598,877500)ng/ml.After rupture,hemoglobin and e-rythrocyte declined and the median trough value of hemoglobin was 69.0(56.3,85.8)g/L.According to the PRETEXT preoperative staging system,the stages Ⅱ(n=1),Ⅲ(n=7)and Ⅳ(n=2).The frequency of TAE was once(n=7)and twice(n=3).After TAE,9/10 cases achieved successful hemostasis.During a medi-an follow-up period of 15.00(3.75,19.25)month,9 patients survived and 1 died.Conclusions HB rupture is quite rare and difficult to treat.There are a heavy tumor burden,poor general status and a progressive decline of hemoglobin.For children responding poorly to hemostatic agents,interventional therapy is recommended.关键词
肝母细胞瘤/破裂/血管内操作/栓塞,治疗性/手术后并发症/治疗/预后/儿童Key words
Hepatoblastoma/Rupture/Endovascular Procedures/Embolization,Therapeutic/Postop-erative Complications/Therapy/Prognosis/Child引用本文复制引用
林宇,常赛朔,阴捷,王焕民,杨深,秦红,杨维,成海燕,常晓峰,冯俊,韩建宇..经导管动脉栓塞术治疗肝母细胞瘤破裂的初步探索[J].临床小儿外科杂志,2023,22(12):1109-1113,5.基金项目
国家自然科学基金重大项目(82293665)National Natural Science Foundation of China(82293665) （82293665）
