临床小儿外科杂志2023，Vol.22Issue(12)：1119-1123,5.DOI:10.3760/cma.j.cn101785-202309028-005
联合肝脏离断和门静脉结扎二步肝切除术治疗儿童巨大肝母细胞瘤
Application of associating liver partition and portal vein ligation during two-stage hepatectomy for mas-sive hepatoblastoma
摘要
Abstract
Objective To explore the efficacy and safety of associating liver partition and portal vein ligation during two-stage hepatectomy(ALPPS)for massive hepatoblastoma.Methods The relevant clinical data were reviewed retrospectively for 4 children with hepatoblastoma undergoing ALPPS between July 2016 and February 2020.Results There were 1 boy and 3 girls with an average age of 39.5 months).ALPPS was suc-cessful.Mean future liver remnant of total liver volume(FLR/TLV)pre-intervention was(12-35.1)％and(16.3-85.2)％before stage Ⅱ resection.The average operation duration and blood loss for stages Ⅰ and Ⅱwere 286 min,150 mL and 127 min,112 mL respectively.No postoperative mortality occurred.One child under-went laparotomy and hepatic duct jejunum Roux-Y anastomosis due to obstructive jaundice after stage Ⅱ resec-tion.During a postoperative follow-up period of(4-14)months,there were tumor-free survival(n=2),lung metastasis during chemotherapy after ALPPS(n=1)and right bone Ewing's sarcoma(n=1).Conclusion-s ALPPS is both efficacious and safe for children with massive hepatoblastoma having insufficient residual liver volume for complete resection.However,more confirmative data should be required and clinical indications of ALPPS further verified in future studies.关键词
肝母细胞瘤/门静脉,外科学/肝切除术/治疗结果/儿童Key words
Hepatoblastoma/Portal Vein,Surgery/Hepatectomy/Treatment Outcome/Child引用本文复制引用
刘百慧,解鲁璐,姚伟,董瑞,李凯,肖现民,董岿然..联合肝脏离断和门静脉结扎二步肝切除术治疗儿童巨大肝母细胞瘤[J].临床小儿外科杂志,2023,22(12):1119-1123,5.基金项目
上海市临床重点专科(shslczdzk05703) （shslczdzk05703）
唐仲英基金会(ZSBK0070) （ZSBK0070）
上海市抗癌协会"雏鹰"计划(SACA-CY22C14)Key Clinical Specialty of Shanghai Municipality(shslczdzk05703) （SACA-CY22C14）
Cyrus Tang Founda-tion(ZSBK0070) （ZSBK0070）
Emerging Talent Project of Shanghai Anticancer Association(SACA-CY22C14) （SACA-CY22C14）
