临床小儿外科杂志2023，Vol.22Issue(12)：1130-1134,5.DOI:10.3760/cma.j.cn101785-202209040-007
m6A修饰在肝母细胞瘤中的研究进展
Research advances of m6A modification in hepatoblastoma
摘要
Abstract
As a rare malignant solid tumor in children,hepatoblastoma(HB)is more common in infants aged 0 to 2 years,accounting for 60％-85％of pediatric liver tumors.The prognosis of advanced HB is rather poor.RNA m6A(N6-methyladenosine,m6A)is an ubiquitous epigenetic modification in eukaryotic RNA.It is extensively implicated in various biological processes of tumors.Many studies have demonstrated that m6A mod-ification plays some vital roles in the occurrence and development of HB.Therefore selecting appropriate detec-tion methods and elucidating the molecular mechanisms of m6A modification are significant for proper manage-ments of HB.Summarizing the latest researches of m6A modification in HB,this review examined its potential val-ue of biological markers or therapeutic targets for HB and provided rationales for new management tools for HB.关键词
肝母细胞瘤/表观基因组学/RNA/m6A修饰Key words
Hepatoblastoma/Epigenomics/RNA/m6A Modification引用本文复制引用
杨丽媛,顾松,王晶,周吉全..m6A修饰在肝母细胞瘤中的研究进展[J].临床小儿外科杂志,2023,22(12):1130-1134,5.基金项目
国家自然科学基金(82072375 （）
82172357) （）
2021年度国家临床重点专科建设项目[沪卫医(2021)99号]National Natural Science Foundation of China(82072375 & 82172357) （2021）
National Key Project of Clinical Specialty Construction(FWY-2021-99) （FWY-2021-99）
