摘要
Abstract
Huangliansu,also known as berberine,is abenzyl tetra isoquinoline alkaloid.Extracted from Coptis chinensis and other plants,it is also a major ingredient of Huanglian Jiedu Decoction,Zuojin Pills and other traditional Chinese medicine prescriptions.It has proved to have a variety of beneficial biological activities for treating infection,inflammation,cardiovascular diseases,gastrointestinal diseases,neurodegeneration,depres-sion and metabolic disorders.Furthermore,it inhibits the proliferation and promotes apoptosis of esophageal cancer,colonic adenocarcinoma,liver cancer,osteosarcoma,breast cancer and other tumor cells through different mechanisms.Also it may act on a variety of cells of pediatric embryonal tumors,such as neuroblastoma,hepato-blastoma and rhabdomyosarcoma.Thus it is a potential antineoplastic drug.Through a literature review,the au-thors summarized the drug effects of berberine in embryonal tumors to provide references for follow-up studies.关键词
小檗碱/胚胎源性肿瘤/神经母细胞瘤/肝母细胞瘤/肾母细胞瘤/儿童Key words
Berberine/Embryonal Tumors/Neuroblastoma/Hepatoblastoma/Nephroblastoma/Child
