摘要
Abstract
Objective:To analyze the clinical efficacy and prognosis of patients with sinonasal malignancy(SNM)treated by endoscopic endonasal approach,and evaluate the changes in quality of life of SNM patients before and after surgery.Methods:In the single-center retrospective cohort study,93 SNM patients who underwent endoscopic endonasal approach in the department of otolaryngology in Suining Central Hospital from January 2016 to December 2020 were taken as the research objects.Clinical data of patients were collected,their prognosis were followed up,and the risk factors affecting the prognosis were analyzed.The quality of life of patients before and after surgery was evaluated by using Sinonasal Outcome Test-22(SNOT-22)and Anterior Skull Base Questionnaire(ASBQ).Results:A total of 93 patients with SNM including squamous cell carcinoma,olfactory neuroblastoma,adenoid cystic carcinoma and other pathological types were included in this study.The majority of patients were in T4 stage(37 cases,39.79%).2 cases had lymph node metastasis and 1 case had distant metastasis.A follow-up with the median duration of 39(6～87)months was completed in 88 patients.During the follow-up,34 patients had tumor recurrence,8 patients died,and 54 patients survived without tumor.The 1-,3-and 5-year overall sur-vival were 93.98%,81.03%and 77.32%,respectively.The results of SNOT-22 showed that the ear,head and face symptoms,mental status and sleep status of the patients significantly improved after surgery(P<0.05);in the dimension of nasal symptoms,postoperative anosmia aggravated and nasal congestion improved.The results of ASBQ showed that the general performance and vitality of the patients significantly improved after surgery(P<0.05);in the dimension of special symptoms,the smell and taste sense of the patients decreased after operation.Conclusion:Selecting appropriate SNM patients for nasal endoscopic treatment can achieve good surgical results and prognosis.Postoperative quality of life of patients treated by endoscopic endonasal approach has improved significantly,but postoperative loss of smell and taste sense is a major concern.关键词
鼻腔鼻窦恶性肿瘤/鼻内镜手术/预后/生活质量Key words
Sinonasal malignancies/Nasal endoscopic surgery/Prognosis/Quality of life分类
医药卫生
