同济大学学报（医学版）2023，Vol.44Issue(6)：835-840,6.DOI:10.12289/j.issn.1008-0392.23073
密骨胶囊对乳腺癌芳香化酶抑制剂相关骨丢失患者骨密度及骨代谢的影响
Effects of Migu capsule on bone mineral density and bone metabolism in breast cancer patients with aromatase inhibitor-associated bone loss
摘要
Abstract
Objective To observe the effects of Chinese medicine Migu capsule combined with caltrate D on bone mineral density(BMD)and bone metabolism in breast cancer patients with aromatase inhibitor-associated bone loss(AIBL).Methods Seventy breast cancer patients with AIBL were randomly divided into study group and control group with 35 cases in each group.All patients received letrozole and caltrate D for treatment for 12 months,and Migu capsules were given to study group additionally.The BMD in the lumbar vertebrae 2-4(L2-L4),greater trochanter,left femoral neck,serum metabolic markers calcium(CA),25 hydroxy vitamin D3(25-OH D3)and bone turnover markers collagen type Ⅰ cross-linked C-terminal peptide(CTX),type Ⅰ collagen cross-linked N-terminal peptide(NTX),procollagen type 1 N-terminal prope-ptide(P1NP)were measured in patients before and after treatment;and safety of medication was evaluated.Results The BMD values of L2-4,greater trochanter,and left femoral neck were significantly increased in the study group and decreased in the control group after treatment(P＜0.05).The 25-OH D3 levels were significantly increased in both groups after treatment(P＜0.05);while the 25-OH D3 level in in the study group was higher than that in the control group(P＜0.001).The[3-CTX and NTX were decreased and P1NP was increased in both groups after treatment(P＜0.05);while the extent of changes in study group was greater than that of the control group(P＜0.001).There was no significant difference in serum estradiol(E2)levels between the two groups before and after treatment(P＞0.05).And there were no significant adverse events in both groups during the treatment.Conclusion The combination of Chinese medicine Migu capsule and caltrate D can increase BMD and improve bone metabolism in breast cancer patients with AIBL.关键词
密骨胶囊/乳腺癌/芳香化酶抑制剂/骨密度/骨代谢Key words
Migu capsule/breast cancer/aromatase inhibitors/bone mineral density/bone metabolism分类
医药卫生引用本文复制引用
王建东,郑洁,刘晖..密骨胶囊对乳腺癌芳香化酶抑制剂相关骨丢失患者骨密度及骨代谢的影响[J].同济大学学报（医学版）,2023,44(6):835-840,6.基金项目
上海市卫生健康委员会中医药科研项目(2018LP036) （2018LP036）
