水生生物学报2024，Vol.48Issue(3)：524-536,13.DOI:10.7541/2024.2023.0208
Pparγ调控鱼类脂质代谢作用机制的研究进展
RESEARCH PROGRESS IN THE MECHANISM OF Pparγ REGULATING LIPID METABOLISM OF FISH
摘要
Abstract
In the process of intensive aquaculture farmed fish commonly suffer from excessive lipid accumulation,which often leads to metabolic disorders,inflammation,and reduction of disease resistance.The above problems se-riously impede the sustainability of aquaculture.As lipid sensors,peroxisome proliferator-activated receptors(PPARs)play an important role in the process of lipid metabolism.PPARs includes three isoforms:PPARα,PPARβ/δ and PPARγ.Notably,PPARγ is considered to be an extremely critical regulator of lipid metabolism,and also plays an important role in the cell differentiation,energy metabolic homeostasis and inflammation.This paper briefly reviewed the regulatory roles of Pparγ on the lipid and fatty acid metabolism,lipid droplet homeostasis,adipocyte differentiation,and its influencing factors,which provide a reference for systematically elucidating the mechanisms of Pparγ on the lipid metabolism in fish,and lay the foundation for promoting the green development of aquaculture.关键词
Pparγ/脂质代谢/调控机制/鱼类Key words
Pparγ/Lipid metabolism/Regulatory mechanisms/Fish分类
生物科学引用本文复制引用
谢帝芝,宋尚书,陈芳,李远友,徐超..Pparγ调控鱼类脂质代谢作用机制的研究进展[J].水生生物学报,2024,48(3):524-536,13.基金项目
国家自然科学基金(31602176) （31602176）
广东省基础与应用基础研究基金(2021A1515011123)资助[Supported by the National Natural Science Foundation of China(31602176) （2021A1515011123）
Guangdong Basic and Applied Basic Research Foundation(2021A1515011123)] （2021A1515011123）
