生物技术通报2023，Vol.39Issue(12)：56-70,15.DOI:10.13560/j.cnki.biotech.bull.1985.2023-0220
S-腺苷-L-甲硫氨酸依赖的3-氨基-3-羧基丙基利用酶研究进展
Research Progress in S-adenosyl-L-methionine Dependent 3-amino-3-carboxypropyl Utilizing Enzymes
摘要
Abstract
S-adenosyl-L-methionine(SAM)is a very important cofactor in biology.It possesses three unstable C-S bonds,which can be selectively cleaved by various SAM-dependent enzymes,catalyzing a wide range of biochemical reactions.Methyltransferases and radical SAM enzymes,which cleave C-S bonds and use methyl and 5'-dexoyadenosine of SAM respectively,have been intensively studied.Over 1.8 million protein sequences of methyltransferases have been deposited in the UniProt database.Radical SAM enzymes have grown into one of the largest enzyme superfamilies,consisting of over 700 000 members.However,enzymes utilizing the 3-amino-3-carboxypropyl(ACP)group of SAM are relatively rarely reported.This paper aims to classify and introduce these enzymes while also provide a prospective research direction for the future.关键词
S-腺苷-L-甲硫氨酸/3-氨基-3-羧基丙基/反应机制/甲基转移酶/非经典SAM自由基酶Key words
S-adenosyl-L-methionine/3-amino-3-carboxypropyl/reaction mechanism/methyltransferase/non-canonical radical SAM enzyme引用本文复制引用
何家乐,董敏..S-腺苷-L-甲硫氨酸依赖的3-氨基-3-羧基丙基利用酶研究进展[J].生物技术通报,2023,39(12):56-70,15.基金项目
国家自然科学基金项目(22277088),天津市自然科学基金(20JCYBJC01100) （22277088）
