生物技术通报2023，Vol.39Issue(12)：118-127,10.DOI:10.13560/j.cnki.biotech.bull.1985.2023-0289
细胞特异性核酸适配体在疾病治疗中的应用
Application of Cell-specific Nucleic Acid Aptamers in Disease Treatment
摘要
Abstract
Nucleic acid aptamers are single-stranded deoxyribonucleic acid(ssDNA)or ribonucleic acid(RNA)composed of 20 to 100 nucleotides,and are generally screened by systematic evolution of ligands by exponential enrichment(SELEX).Aptamers can specifically bind to a variety of target substances,including toxins,metal ions,biological macromolecules,microorganisms,etc.,and have been widely used in food detection,medical diagnosis,and other fields.As the most basic unit of the human body,cells are the focus of research on the pathological mechanism and treatment strategy of most diseases.In recent years,nucleic acid therapy has become the focus of research in the field of disease treatment with the advantages of safer and more efficient one.Researchers realized that the targeted binding ability of nucleic acid aptamers can be applied to cell targeted therapy.Cell-specific aptamers are different from traditional aptamers in that their specific targets are cellular components.They can directly bind to substances related to cell growth and metabolism to affect cell physiological activities,and can also be used as targeted delivery tools to deliver drugs,which has a breakthrough effect in the precision treatment of diseases.Cell-specific nucleic acid aptamers have attracted much attention.In this article,we review the research progress of cell-specific nucleic acid aptamers in the treatment of a variety of diseases in order to provide reference for their application in the treatment of human diseases.关键词
核酸适配体/细胞特异性/核酸疗法/靶向治疗/疾病治疗Key words
nucleic acid aptamers/cell-specific/nucleic acid therapy/targeted therapy/disease treatment引用本文复制引用
钟朝滨,朱龙佼,张博洋,张洋子,陈可仁,许文涛..细胞特异性核酸适配体在疾病治疗中的应用[J].生物技术通报,2023,39(12):118-127,10.基金项目
北京市设施蔬菜创新团队项目(BAIC01),国家自然科学基金国家重大科研仪器研制项目(2192780096),中国农业大学 2115人才工程资助(00109012) （BAIC01）
