宿州学院学报2023，Vol.38Issue(12)：23-27,5.DOI:10.3969/j.issn.1673-2006.2023.12.005
灵芝孢子油体内外抗氧化作用研究
Study on the Antioxidant Effects of Ganoderma lucidum Spore Oil in Vivo and in Vitro
摘要
Abstract
In order to study the antioxidant effects of Ganoderma lucidum spore oil(GLSO)in vivo and in vitro,the scavenging rates of DPPH,ABTS and·O2- free radicals by GLSO were measured in vitro,and D-galactose was used to construct a senescent mouse model in vivo.The contents of SOD,CAT and MDA in serum and liver tissue and the expression level of PI3K/AKT in liver tissue of senescent mice were determined.The results showed that the scaven-ging effect of GLSO on DPPH,ABTS and·O2- free radicals was equivalent to 84.05％,22.05％and 46.48％of that of VC.Compared with blank group,SOD and CAT in serum and liver of model group decreased,while MDA in-creased.The ratio of p-AKT/AKT and p-PI3K/PI3K decreased,and there was a certain dependence effect between different doses.The results suggested that GLSO might play an antioxidant role by activating the PI3K/AKT path-way.关键词
灵芝孢子油/D-半乳糖/衰老小鼠/PI3K/AKT通路/抗氧化作用Key words
Ganoderma lucidum spore oil/D-galactose/Senescent mouse/PI3K/AKT pathway/Antioxidant effect分类
轻工纺织引用本文复制引用
向世东,张广磊,周功强,黄文康,陈浩,俞浩..灵芝孢子油体内外抗氧化作用研究[J].宿州学院学报,2023,38(12):23-27,5.基金项目
安徽高校协同创新项目(GXXT-2019-043) （GXXT-2019-043）
固镇县省级农业科技园区研发项目(固科字[2020]19号) （固科字[2020]19号）
亳州学院产学研合作项目(BYH202106). （BYH202106）
