摘要
Abstract
Objective:To evaluate the efficacy and safety of Chinese medicine combined with aspirin in the treatment of recurrent abortion.
Methods:The randomized controlled clinical trials(RCT)about Chinese medicine combined therapy with aspirin in patients with recurrent abortion were searched from China National Knowledge Network(CNKI),Wanfang Database(WF),VIP Journal Database,China Biomedical Literature Database,PubMed,Web of science from establishment of database to March 2023.The patients in the control group received conventional treatment,and the patients in experimental group were treated with traditional Chinese medicine combined with aspirin based on clinical routine treatment.Two researchers independently searched literature,collected data and assessed the bias risk.Statistical analysis was performed using RevMan5.4.1 software.The safety analysis and sensitivity analysis were conducted,and funnel plot was used to evaluate potential publication bias.
Results:Nineteen randomized controlled studies were included,with a total of 1 265 patients.Meta-analysis results showed that Chinese medicine combined with aspirin significantly improved the pregnancy rate,the negative conversion rate of anti-cardiolipin antibody(ACA)(P＜0.05).It also significantly increased the levels of activated partial thromboplastin time(APTT),the levels of HCG,progesterone(P),estradiol(E2),and reduced the levels of fibrinogen(FIB)and D-dimer(D-D).However,the improvement of prothrombin time(PT)and thrombin time(TT)may not had a significant therapeutic advantage(P＞0.05).
Conclusions:The use of traditional Chinese medicine combined with aspirin in the treatment of recurrent abortion can improve the high coagulation of pregnancy women,increase the hormones levels and the negative conversion rate of ACA,so as to improve the pregnancy rate of patients.However,further research on the mechanism of action is needed,and larger sample,high-quality randomized controlled trials also need to be included for validation.关键词
中药/阿司匹林/随机对照试验/Meta分析/复发性流产Key words
Traditional Chinese medicine/Aspirin/Randomized controlled trial/Meta-analysis/Recurrent spontaneous abortion分类
医药卫生
