针刺调控缺血性卒中后神经元线粒体的作用机制研究进展OACSTPCD

Acupuncture has a positive effect in the treatment of ischemic stroke(IS).A number of studies have confirmed that the role of acupuncture in the treatment of IS,which is closely related to its functions of regulating mito-chondrial functions.In the present article,we review the mechanisms of acupuncture underlying improvement of mito-chondria in the treatment of IS from 4 aspects:1)protecting mitochondrial structure integrity,2)regulative effect on mi-tochondrial functional activities,including regulating energy metabolism,reducing oxidative stress,suppressing calcium overload,and regulating mitochondrial membrane potential changes,3)regulating mitochondrial quality control sys-tem,including promoting mitochondrial biosynthesis,regulating mitochondrial dynamics and apoptosis,and 4)regula-ting mitochondria-related apoptosis pathways.All of these may provide a theoretical basis for acupuncture in the treat-ment of IS and a reference for further research.