针刺研究2024，Vol.49Issue(1)：71-78,8.DOI:10.13702/j.1000-0607.20220909
针刺调控缺血性卒中后神经元线粒体的作用机制研究进展
Advances of research on mechanisms of acupuncture underlying improvement of ischemic stroke by regulating neuronal mitochondria
摘要
Abstract
Acupuncture has a positive effect in the treatment of ischemic stroke(IS).A number of studies have confirmed that the role of acupuncture in the treatment of IS,which is closely related to its functions of regulating mito-chondrial functions.In the present article,we review the mechanisms of acupuncture underlying improvement of mito-chondria in the treatment of IS from 4 aspects:1)protecting mitochondrial structure integrity,2)regulative effect on mi-tochondrial functional activities,including regulating energy metabolism,reducing oxidative stress,suppressing calcium overload,and regulating mitochondrial membrane potential changes,3)regulating mitochondrial quality control sys-tem,including promoting mitochondrial biosynthesis,regulating mitochondrial dynamics and apoptosis,and 4)regula-ting mitochondria-related apoptosis pathways.All of these may provide a theoretical basis for acupuncture in the treat-ment of IS and a reference for further research.关键词
缺血性卒中/针刺/线粒体/线粒体功能障碍/综述Key words
Ischemic stroke/Acupuncture/Mitochondria/Mitochondrial dysfunction/Review引用本文复制引用
李昱萱,张润琛,程爱新,马庆韬,付天聪,王冠然,徐枝芳,郭扬..针刺调控缺血性卒中后神经元线粒体的作用机制研究进展[J].针刺研究,2024,49(1):71-78,8.基金项目
国家自然科学基金青年基金项目(No.82004464) （No.82004464）
天津市自然科学基金青年基金项目(No.20JCQNJC00920) （No.20JCQNJC00920）
中华中医药学会青年人才托举工程项目[No.CACM-(2022-QNRC2-A09)] （2022-QNRC2-A09）
