中国临床药学杂志2023，Vol.32Issue(6)：422-426,5.DOI:10.19577/j.1007-4406.2023.06.005
利妥昔单抗联合免疫抑制剂对特发性膜性肾病的临床疗效
Clinical effect of rituximab combined with in treatment of idiopathic membranous nephropathy
摘要
Abstract
AIM To investigate the clinical efficacy of rituximab in combination with immunosuppressants in patients with idiopathic membranous nephropathy(IMN).METHODS A total of 129 patients with IMN from August 2018 to August 2020 were selected as study subjects and randomly divided into 3 groups,with 43 cases in each group.Control group A was treated with cyclophosphamide,control group B was treated with rituximab,and observation group was treated with rituximab combined with cyclophosphamide.The disease remission rate,nephropathy-related indexes,T lymphocyte subpopulation,urinary tapping membrane complex(C5b-9),immunoglobulin G4(IgG4),relapse rate and the incidence of infection complications were compared among 3 groups.RESULTS The disease remission rate in the observation group was higher than that in control groups A and B(P＜0.05);the 24 h urine protein quantification,urine C5b-9 and IgG4 in the observation group were lower than those in control groups A and B after treatment,and serum albumin in the observation group was higher than that in control groups A and B(P＜0.05);CD4+,CD4+/CD8+were lower in the observation group after treatment than in control groups A and B groups,and CD8+was higher than control A and B groups;the 12-month recurrence rate was lower in the observation group than control A and B groups(P＜0.05);the differences were not statistically significant when comparing infection complications in 3 groups(P>0.05).CONCLUSION Rituximab combined with immunosuppressants can effectively alleviate IMN disease and improve renal and immune function,and is safe and reliable.关键词
利妥昔单抗/免疫抑制剂/特发性膜性肾病/感染/免疫功能Key words
rituximab/immunosuppression/idiopathic membranous nephropathy/infection/immune function引用本文复制引用
聂丽敏,姚杏,融雪,张珊珊,张兵,张烨,张琪,付洁琼,薛兰芬..利妥昔单抗联合免疫抑制剂对特发性膜性肾病的临床疗效[J].中国临床药学杂志,2023,32(6):422-426,5.基金项目
石家庄市科学技术研究与发展指导计划项目(编号191460523) （编号191460523）
