摘要
Abstract
Objective To explore the predictive value of D-Dimer and thromboelastography(TEG)for the occurrence of tumor-related thrombus in elderly patients hospitalized with malignant tumors.Methods 121 cases of elderly malignant tumor inpatients aged 60 years and above admitted to our hospital from May 2022 to May 2023 were selected for analysis,and were divided into the thrombus group(observation group)and the non-thrombus group(control group)according to whether or not tumor-related thrombus occurred,with a focus on the comparative analysis of the TEG indexes between the two groups[reaction time(R),coagulation time(K),coagulation angle,maximum amplitude(MA)]and coagulation assay levels.The occurrence of tumor-associated thrombosis in elderly patients with malignant tumors was counted,and the factors affecting the occurrence of tumor-associated thrombosis were ana-lyzed.Results The results of correlation analysis showed that tumor stage,long-term bed rest,D-Dimer,R and MA levels were in-dependent risk factors for the occurrence of TAT in elderly patients with malignant tumors(P<0.05),and the level of D-Dimer in the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).The value of R in the TEG indexes increased with the increase of the risk grade for the occurrence of deep venous thrombosis in patients with malignant tumors R value in TEG index decreased with the increase of risk grade of DVT in malignant tumor pa-tients,MA value increased with the increase of risk grade of DVT in malignant tumor patients,and the difference was statistically sig-nificant(P<0.05).The area under the curve of D-Dimer,R value,MA value and the combined diagnosis for predicting the occur-rence of TAT in elderly malignant tumor patients were 0.667,0.725,0.715,and 0.804.Conclusion The R value of D2 polymor-phism as well as the R value in the index of TEG,MA values are valuable for the prediction of treatment-related venous thrombosis in elderly patients hospitalized with malignant tumors.The above indexes can be used for early identification of DVT in elderly malig-nant tumor hospitalized patients.关键词
血栓弹力图/常规凝血试验/老年人/静脉血栓/危险因素Key words
thromboelastography/conventional coagulation test/elderly/venous thrombosis/risk factors
