中国老年保健医学2023，Vol.21Issue(6)：69-72,4.DOI:10.3969/j.issn.1672-2671.2023.06.014
糖尿病COPD患者合并肺部感染的病原菌特征及耐药分析
Analysis of pathogen characteristics and drug resistance of diabetic COPD complicated with pulmonary infection
摘要
Abstract
Objective Analysis the distribution and drug sensitivity of diabetic COPD complicated with bacterial pneumonia,so as to provide reference for clinical rational use of drugs.Methods Totally 74 cases of diabetic COPD with bacterial pneumonia from 2017 to 2022 were selected as the observation group,and 112 cases of COPD with bacterial pneumonia in the same period were se-lected as the control group.The two groups were treated with phlegm culture and drug sensitivity test to compare for the distribution of pathogenic bacteria and drug sensitivity.Results In the observation group,106 strains of pathogenic bacteria were detected,of which Gram-negative bacteria(G-)accounted for63.21%(67 strains).The main Gram-negative bacteria was Klebsiella pneu-moniae(29.25%),Pseudomonas aeruginosa(16.98%),and Acinetobacter Bauman(8.49%),other there were 26 fungi(24.53%),Gram-positive bacteria(G+)accounted for 12.26%(13 strains),32 cases of mixed infection(30.19%).In the control group,124 strains of pathogenic bacteria were detected,with Gram-negative bacteria accounting for 62.90%(78 strains),Gram-positive bacteria accounting for 22.58%(28 strains)and fungi accounting for 14.52%(18 strains).The fungal and mixed infection rates of the observation group were higher than those of the control group,the detection rate of Gram-positive bacteria was lower than that of the control group,it is statistically significant differences.The drug resistance rate of the observation group was all higher than that of the control group(except cefazolin and penicillin).Gram-negative bacteria was highly sensitive to imipenem and amikacin,and Gram-positive bacteria was highly sensitive to tycorrine and vancomycin.Conclusion The diabetic COPD complicat-ed with bacterial pneumonia are mainly Gram-negative bacillus infections such as klebsiella pneumoniae,pseudomonas aeruginosa and acinetobacter baumannii,which have high drug resistance.The clinical monitoring of pathogenic bacteria should be strengthened to avoid fungal and mixed bacterial infections caused by the abuse of antibiotics.关键词
慢性阻塞性肺病/糖尿病/细菌性肺炎/病原菌/耐药性Key words
chronic obstructive pulmonary disease/diabetes/bacterial pneumonia/pathogen/drug resistance引用本文复制引用
龙辉,李阿宁,罗云..糖尿病COPD患者合并肺部感染的病原菌特征及耐药分析[J].中国老年保健医学,2023,21(6):69-72,4.基金项目
重庆市科卫联合课题项目(编号:2021ZY3712) （编号:2021ZY3712）
