中国斜视与小儿眼科杂志2023，Vol.31Issue(4)：32-36,5.DOI:10.3969/J.ISSN.1005-328X.2023.04.012
屈光参差性弱视儿童弱视治疗前后光学相干断层扫描和图形视网膜电图的改变
Changes of optical coherence tomography(OCT)and pattern electroretinogram(PERG)in children with ani-sometropic amblyopia before and after treatment
摘要
Abstract
Objective To investigate the changes of retinal structure and function in patients with anisometropic am-blyopia before and after treatment,in order to further understand whether there is damage to retinal microstructure and reti-nal function in amblyopia patients,and whether there is change in retinal microstructure and retinal function after effective amblyopia treatment.Methods Thirty children(8～13 years old)with anisometropia amblyopia were recruited.The axial length,diopter,strabismus,retinal nerve fiber layer(RNFL)thickness,ganglion cell complex(GCC)mean thick-ness,P50,N95 amplitude and latency were measured and recorded before and after treatment using OCT and PERG.Results The average GCC thickness of amblyopic eyes(AE)was thicker than that of contralateral healthy eyes(FE)in visual sensitive period(t=2.264,P=0.039).The thickness of RNFL increased significantly in the upper(t=3.970,P=0.001),nasal(t=3.307,P=0.005),and lower(t=5.573,P=0.001).The thickness of temporal RNFL layer was thinner than that of contralateral healthy eyes(t=-2.353,P=0.033).In addition,the P50 amplitude(t=-4.108,P=0.001)and N95 amplitude(t=-3.126,P=0.006)of PERG in amblyopic eyes were significantly lower than those in contralateral healthy eyes.After 3 months of covering treatment,the best corrected visual acuity(BCVA)of the subjects was significantly improved compared with that before treatment(t=-0.224,P=0.034),but the RNFL,GCC thickness and PERG were not significantly changed.Compared with the contralateral healthy eyes,the changes of OCT and PERG in the amblyopic eyes after treatment were consistent with those before treatment.Conclusions The results of this study suggest that the improvement of visual acuity in patients with amblyopia after treat-ment may be due to the visual center rather than the restoration of retinal structure or function.关键词
屈光参差性弱视/光学相干断层扫描/图形视网膜电图/遮盖疗法Key words
Anisometropic amblyopia/Optical oherence tomography/Pattern electroretinogram/Cover-up therapy引用本文复制引用
彭小宁,李盈龙,王光鑫,喻静文,刘帅..屈光参差性弱视儿童弱视治疗前后光学相干断层扫描和图形视网膜电图的改变[J].中国斜视与小儿眼科杂志,2023,31(4):32-36,5.基金项目
合肥市科委基金应用医学项目(Hwk2021yb004) （Hwk2021yb004）
安徽医科大学校青年基金项目(2020xkj067) （2020xkj067）
