中国医药科学2023，Vol.13Issue(24)：26-29,86,5.DOI:10.20116/j.issn2095-0616.2023.24.06
GPX4相关的中枢神经系统疾病及其治疗进展
GPX4-related central nervous system disease and its treatment progress
摘要
Abstract
The central nervous system(CNS)is the main part of the human nervous system and is the most refined and complex system in terms of structure and function in the human body.Owing to the structural foundation of CNS,CNS diseases are diversified,and the pathogenesis is profound and complex.The basic unit that constitutes CNS is nerve cells,and the damage or even death of cells is the fundamental mechanism of many CNS diseases.Ferroptosis is a cell death pathway discovered in recent years,and ferroptosis of nerve cells plays an important role in the pathogenesis of many CNS diseases.Glutathione peroxidase 4(GPX4),as a critical enzyme in the regulatory pathway of ferroptosis,has become an important target of many CNS disease treatment researches.Therefore,this article focuses on the critical mechanism of GPX4 regulation in ferroptosis and the research progress in the treatment of CNS diseases related to GPX4 in recent years,hoping to provide directions for future research on CNS disease treatment.关键词
谷胱甘肽过氧化物酶4/铁死亡/中枢神经系统疾病/治疗Key words
Glutathione peroxidase 4/Ferroptosis/Central nervous system disease/Treatment分类
医药卫生引用本文复制引用
蔡文慧,马凌云,霍丽蓉..GPX4相关的中枢神经系统疾病及其治疗进展[J].中国医药科学,2023,13(24):26-29,86,5.基金项目
北京市西城区优秀人才拔尖团队项目(201915) （201915）
首都医科大学"本科生科研创新"项目(XSKY2022316). （XSKY2022316）
