中国医院用药评价与分析2023，Vol.23Issue(12)：1450-1453,4.DOI:10.14009/j.issn.1672-2124.2023.12.008
血府逐瘀汤加减联合盐酸赛庚啶片治疗血瘀型偏头痛的临床观察
Clinical Observation of Modified Xuefu Zhuyu Decoction Combined with Cyprohepidine Hydrochloride Tablets in the Treatment Migraine of Blood-Stasis Pattern
摘要
Abstract
OBJECTIVE:To explore the clinical efficacy of modified Xuefu Zhuyu decoction combined with Cyprohepidine hydrochloride tablets in the treatment migraine of blood-stasis pattern.METHODS:Totally 92 patients with migraine of blood-stasis pattern admitted into the hospital from Feb.2021 to Feb.2023 were extrected to be divided into the observation group and the control group via the random number table method,with 46 cases in each group.The control group was treated with Cyprohepidine hydrochloride tablets,while the observation group received Xuefu Zhuyu decoction on the basis of the control group.The clinical efficacy,traditional Chinese medicine syndrome score and symptom improvement(headache attack frequency,headache duration,headache visual simulation score and migraine specific quality of life questionnaire score),serum neurotransmitters(calcitonin gene-related peptide,5-hydroxytryptamine and dopamine),cerebral artery flow velocity(anterior cerebral artery,middle cerebral artery,posterior cerebral artery and vertebral artery),recurrence rate and safety of two groups were observed before and after treatment.RESULTS:After treatment,the total effective rate of observation group was 91.30%(42/46),significantly higher than that of control group 73.91%(34/46),with statistically significant difference(P<0.05).After treatment,the traditional Chinese medicine syndrome score,headache visual simulation score,headache attack frequency,headache duration and cerebral artery blood flow velocity of two groups were lower than those before treatment,the above indicators in observation group were improved more significantly compared with control group,the differences were statistically significant(P<0.05).The levels of serum calcitonin gene-related peptide,5-hydroxytryptamine,dopamine and migraine specific quality of life questionnaire in both groups after treatment were higher than those before treatment,and the observation group was higher than the control group,with statistically significant differences(P<0.05).The recurrence rate of observation group was 6.52%(3/46),significantly lower than that of control group 23.91%(11/46),with statistically significant differences(P<0.05).CONCLUSIONS:The efficacy of modified Xuefu Zhuyu decoction combined with Cyprohepidine hydrochloride tablets in the treatment migraine of blood-stasis pattern is significant.关键词
血府逐瘀汤/盐酸赛庚啶片/血瘀型/偏头痛/神经递质/脑动脉血流Key words
Xuefu Zhuyu decoction/Cyproheptadine hydrochloride tablets/Blood-stasis pattern/Migraine/Neurotransmitter/Cerebral arterial flow分类
医药卫生引用本文复制引用
师虹艳,杨少坤,荀军锋,张晨柳,李智申..血府逐瘀汤加减联合盐酸赛庚啶片治疗血瘀型偏头痛的临床观察[J].中国医院用药评价与分析,2023,23(12):1450-1453,4.基金项目
河北省中医药管理局科研计划项目(No.2023149) （No.2023149）
